ArticleFrontiers in endocrinology2022
Glioma Subtypes Based on the Activity Changes of Immunologic and Hallmark Gene Sets in Cancer.
Article in Frontiers in endocrinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.
- KIF2C/MCAK a prognostic biomarker and its oncogenic potential in malignant progression, and prognosis of cancer patients: a systematic review and meta-analysis as biomarker.Critical reviews in clinical laboratory sciences · 2024Pooled it
- The deficiency of KIF2C leads to abnormal distribution of cortical neurons and behavioral deficits in mice.iScience · 2026Article
- RUNX2 drives adenoma-to-carcinoma transition in colon cancer.Cell death & disease · 2026Article
- KIF20A inhibits TRIM21-dependent ubiquitination of DHX9 to boost SOX2 stability, enhancing OSCC stemness and ferroptosis resistance.Cell death & disease · 2026Article
- The analysis of TOP2A as a potential target for predicting the prognosis of brain glioma in the TCGA database and in single-center study.Discover oncology · 2025Article
- Comprehensive analysis of IGF2BP3 with expression features, prognosis, immune modulation and stemness in hepatocellular carcinoma and pan-cancer.Journal of Cancer · 2024Article
- Eg5 and Diseases: From the Well-Known Role in Cancer to the Less-Known Activity in Noncancerous Pathological Conditions.Biochemistry research international · 2024Review
- Glioma Subtypes Based on the Activity Changes of Immunologic and Hallmark Gene Sets in Cancer.Frontiers in endocrinology · 2022Article
- Screening and Biological Function Analysis of miRNA and mRNA Related to Lung Adenocarcinoma Based on Bioinformatics Technology.Journal of oncology · 2022Article
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Authors and funding
1 author at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Purpose: Glioma is the most common primary cranial brain tumor that arises from the cancelation of glial cells (which can be in the brain or spinal cord). It is due to innate genetic risk factors or induced by a carcinogenic environment. If left untreated, the disease has a poor prognosis. Methods: In this study, we downloaded glioma data from TCGA database and GEO (GSE4412). The GSEA database was used to screen tumor microenvironment-related gene sets. Cancer subtypes were classified by GSVA enrichment method. Results: By GSVA enrichment analysis, we obtain three Gliomas cancer subtypes. After further survival prognosis analysis and biological function analysis, we obtained 13 tumor microenvironment gene sets and 14 core genes that affect patients' survival prognosis, and these genes have the potential to become targets for targeted therapies and disease detection. Conclusion: We screened a total of 13 gene sets through a series of enrichment analyses, statistical and prognostic analyses, etc. Among them, 14 core genes were identified, namely: TOP2A, TPX2, BUB1, AURKB, AURKA, CDK1, BUB1B, CCNA2, CCNB2, CDCA8, CDC20, KIF11, KIF20A and KIF2C.
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