ArticleStatistics in medicine2022
Analysis of stepped wedge cluster randomized trials in the presence of a time-varying treatment effect.
Article in Statistics in medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
46 citing papers in PubMed.
- Implementation outcomes of a symptom management intervention in ambulatory oncology practices evaluated using a cluster randomized stepped-wedge trial design.Implementation science : IS · 2025Trial
- Implementation of First-Trimester Screening and Prevention of Preeclampsia: A Stepped Wedge Cluster-Randomized Trial in Asia.Circulation · 2024Trial
- Using the NIH Research Methods Resources Website.Prevention science : the official journal of the Society for Prevention Research · 2026Article
- Additional crossovers in cluster randomised crossover trials do not always increase statistical power.Clinical trials (London, England) · 2026Article
- Comparing meta-analysis and linear mixed model-based approaches for the analysis of continuous outcomes from batched stepped wedge trials.Clinical trials (London, England) · 2026Article
- Evaluation of injury prevention interventions using the stepped wedge cluster randomised trial design: key considerations.Injury prevention : journal of the International Society for Child and Adolescent Injury Prevention · 2026Article
- Diagnostic stewardship in emergency departments using the UNTIE framework: a stepped-wedge cluster randomised study protocol.BMJ open · 2026Article
- Evaluating global health programmes targeting under-5 mortality: problems and recommendations.BMJ global health · 2026Article
- CRT-Estimands Framework: consensus based extension of the ICH E9(R1) addendum for cluster randomised trials.BMJ (Clinical research ed.) · 2026Article
- Model-robust standardization in stepped wedge cluster randomized trials.Journal of the Royal Statistical Society. Series A, (Statistics in Society) · 2026Article
- Analysis of Stepped-Wedge Cluster Randomized Trials: A Tutorial Using Marginal Models.Statistics in medicine · 2026Article
- Factors affecting power in stepped wedge trials when the treatment effect varies with time.Trials · 2026Article
- A sensitivity analysis approach to principal stratification with a continuous longitudinal intermediate outcome: applications to a cohort stepped wedge trial.Biostatistics (Oxford, England) · 2026Article
- Gaming the System: Evaluating Spillover in a Video Game Intervention for Advance Care Planning using Physician Social Networks.Health services & outcomes research methodology · 2026Article
- Steps toward developing an algorithm to facilitate recognition of translational science.Journal of clinical and translational science · 2026Article
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- What scientific inferences can be made with randomized implementation rollout trials.Implementation science : IS · 2025Article
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- Selecting the optimal longitudinal cluster randomized design with a continuous outcome: Parallel-arm, crossover, or stepped-wedge.Statistical methods in medical research · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Stepped wedge cluster randomized controlled trials are typically analyzed using models that assume the full effect of the treatment is achieved instantaneously. We provide an analytical framework for scenarios in which the treatment effect varies as a function of exposure time (time since the start of treatment) and define the "effect curve" as the magnitude of the treatment effect on the linear predictor scale as a function of exposure time. The "time-averaged treatment effect" (TATE) and "long-term treatment effect" (LTE) are summaries of this curve. We analytically derive the expectation of the estimator
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.