Evidence map›Paper›PMID 35773944›Full record

ArticleInternational journal of rheumatic diseases2022

Covid-19 vaccination in autoimmune rheumatic diseases: A multi-center survey from southern India.

Kavitha Mohanasundaram, Sham Santhanam, Raja Natarajan, Hema Murugesan, Thilagavathy Nambi, Balaji Chilikuri, Subramanian Nallasivan

Open access · bronzeAbstract readMulticenter Study
In one paragraph

Article in International journal of rheumatic diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
2.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 28 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 7 institutions in 1 country.

Kavitha MohanasundaramRheumatology, Saveetha Medical College Hospital, Chennai, India.ORCID https://orcid.org/0000-0002-8921-4210
Sham SanthanamRheumatology, Gleneagles Global and Vijaya hospitals, Chennai, India.ORCID https://orcid.org/0000-0002-3672-9245
Raja NatarajanPadmavathy Rheumatic Care Centre, Sri Narayani Hospital and Research Centre, Vellore, India.
Hema MurugesanRheumatology, Stanley Medical College, Chennai, India.
Thilagavathy NambiSIMS Hospital, Chennai, India.
Balaji ChilikuriDepartment of Rheumatology, Sri Ramachandra Medical College and Research Institute, Chennai, India.
Subramanian NallasivanDepartment of Rheumatology and Medicine, Velammal Medical College Hospital and Research Institute, Madurai, India.
ACS Medical College and Hospital · INGlobal Hospitals · INSaveetha University · INSri Narayani Hospital & Research Centre · INSri Ramachandra Institute of Higher Education and Research · INStanley Medical College · INVelammal Medical College Hospital and Research Institute · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimThis survey was conducted to evaluate COVID-19 vaccination status in patients with autoimmune rheumatic diseases (AIRDs). Our objectives were to study vaccine hesitancy, adverse effects, breakthrough infections and flare of underlying disease in this population subgroup.

methodsThis was a multi-center, cross-sectional, interview-based survey done at 6 tertiary care centers across Tamil Nadu, in the southern part of India from September 15, 2021 to October 14, 2021. The survey questionnaire was filled up by AIRD patients attending their clinics. The survey questionnaire comprised a set of 14 questions, distributed between patient characteristics, vaccines taken, their characteristics and COVID-19 infection.

resultsThere were 2092 participants, with a mean age of 47.5 ± 13.17 years. Among them, 1293 (61.81%) were vaccinated, of which 837 (64.73%) were fully vaccinated. Two-thirds of our subjects were vaccinated with ChAdOx1 nCov-19 (COVISHIELD) (77.64%) and 21.57% with BBV 152 (COVAXIN). Age, gender, education and comorbidities had no association with vaccine hesitancy. The commonest (421; 52.69%) reason for vaccine hesitancy was fear of side effects. The incidence (n = 72) of breakthrough infections was similar in both the vaccine groups, of which 58 (80.55%) were partially vaccinated and 14 (19.44%) were fully vaccinated. Thirty-two patients had a flare of pre-existing rheumatic disease.

conclusionChAdOx1 nCov-19 and BBV 152 were found to be safe in patients with rheumatic diseases. Fear of side effects was the major cause of vaccine hesitancy. All adverse effects were minor and self-limiting. Breakthrough infections and disease flares occurred only in a small subset of our cohort.

Indexed as

Autoimmune DiseasesCOVID-19COVID-19 VaccinesRheumatic DiseasesAdultChAdOx1 nCoV-19Cross-Sectional StudiesHumansIndiaMiddle AgedSurveys and QuestionnairesVaccinationVaccination HesitancyChAdOx1 nCoV-19COVID-19 VaccinesChAdOx1 nCoV 19COVID-19 breakthrough infectionsCOVID 19 vaccinesside effectsvaccine hesitancy

Identifiers

PMID35773944
PMCPMC9349850
OpenAlexW4283740167

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.