Evidence map›Paper›PMID 35773721›Full record

ArticleMolecular autism2022

Diagnostic validity of Autism Diagnostic Observation Schedule, second edition (K-ADOS-2) in the Korean population.

So Yoon Kim, Miae Oh, Guiyoung Bong, Da-Yea Song, Nan-He Yoon, Joo Hyun Kim, Hee Jeong Yoo

Abstract read
In one paragraph

Article in Molecular autism, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Double-blind, sham-controlled, pilot study of trigeminal nerve stimulation for autism spectrum disorder.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

So Yoon Kim *Teacher Education, Duksung Women's University, Seoul, South Korea.
Miae Oh *Department of Psychiatry, Kyung Hee University Hospital, Seoul, South Korea.
Guiyoung BongDepartment of Psychiatry, Seoul National University Bundang Hospital, Seoul National University College of Medicine, 300 Gumi-ro, Bundang-gu, Seongnam, Gyeonggi, 463-707, South Korea.
Da-Yea SongDepartment of Psychiatry, Seoul National University Bundang Hospital, Seoul National University College of Medicine, 300 Gumi-ro, Bundang-gu, Seongnam, Gyeonggi, 463-707, South Korea.
Nan-He YoonDivision of Social Welfare and Health Administration, Wonkwang University, Iksan, South Korea.
Joo Hyun KimDepartment of Psychiatry, Seoul National University Bundang Hospital, Seoul National University College of Medicine, 300 Gumi-ro, Bundang-gu, Seongnam, Gyeonggi, 463-707, South Korea.
Hee Jeong YooDepartment of Psychiatry, Seoul National University Bundang Hospital, Seoul National University College of Medicine, 300 Gumi-ro, Bundang-gu, Seongnam, Gyeonggi, 463-707, South Korea. hjyoo@snu.ac.kr.ORCID 0000-0003-0521-2718

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAlthough the Korean version of the Autism Diagnostic Observation Schedule-2 (K-ADOS-2) is widely being used to diagnose autism spectrum disorder (ASD) in South Korea, no previous study has examined the validity and reliability of all modules of K-ADOS-2 across a wide age range, particularly older children, adolescents, and adults.

methodData from 2,158 participants were included (mean age = 79.7 months; 73.6% male): 1473 participants with ASD and 685 participants without ASD (Toddler Module, n = 289; Module 1, n = 642; Module 2 n = 574; Module 3 n = 411; Module 4, n = 242). Participants completed a battery of tests, including the K-ADOS or K-ADOS-2 and other existing diagnostic instruments. Sensitivity, specificity, area under the receiver operating characteristic (ROC) curve, positive predictive value (PPV), negative predictive value (NPV), Cohen's kappa (k), and agreement with existing diagnostic instruments were computed. Cronbach's α values were also calculated.

resultsAll developmental cells of the K-ADOS-2 showed sufficient ranges of sensitivity 85.4-100.0%; specificity, 80.4-96.8%; area under the ROC curve, .90-.97; PPV, 77.8-99.3%; NPV, 80.6-100.0%; and k values, .83-.92. The kappa agreements of developmental cells with existing diagnostic instruments ranged from .20 to .90. Cronbach's α values ranged from .82 to .91 across all developmental cells. LIMITATION: The best-estimate clinical diagnoses made in this study were not independent of the K-ADOS-2 scores. Some modules did not include balanced numbers of participants in terms of gender and diagnostic status.

conclusionThe K-ADOS-2 is a valid and reliable instrument in diagnosing ASD in South Korea. Future studies exploring the effectiveness of the K-ADOS-2 in capturing restricted, repetitive behaviors and differentiating ASD from other developmental disabilities are needed.

Indexed as

Autism Spectrum DisorderAutistic DisorderAdolescentAdultAsian PeopleChildFemaleHumansMaleReproducibility of ResultsROC CurveADOS-2AutismDiagnosisValidity

Identifiers

PMID35773721
PMCPMC9245227

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.