SynthesisBMC neurology2022
Early predictors of functional outcome in poor-grade aneurysmal subarachnoid hemorrhage: a systematic review and meta-analysis.
Synthesis in BMC neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.
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Who cites it
27 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Timing of aneurysm repair and clinical outcomes after aneurysmal subarachnoid hemorrhage: a systematic review.Journal of neurology · 2026Pooled it
- Prognostic nutritional indices and functional outcome in patients with subarachnoid hemorrhage: a meta-analysis.Neurosurgical review · 2025Pooled it
- Personalized decision-making for aneurysm treatment of aneurysmal subarachnoid hemorrhage: development and validation of a clinical prediction tool.BMC neurology · 2024Pooled it
- Microsurgical clipping of paraclinoid aneurysms: a 12-year single-centre experience with surgical nuances and outcomes.Neurosurgical review · 2026Article
- Extracranial organ dysfunction in non-traumatic subarachnoid hemorrhage: a retrospective single center cohort study.BMC anesthesiology · 2026Article
- Acute-phase bypass surgery for ruptured intracranial aneurysm: Selection criteria in the endovascular era.Surgical neurology international · 2026Article
- Functional recovery patterns from discharge to 12 months after endovascular treatment for aneurysmal subarachnoid hemorrhage: a multicenter cohort study.Frontiers in neuroscience · 2026Article
- Intra-arterial nimodipine and outcomes in delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage.Brain & spine · 2026Article
- Comparative Analysis of Single-Stage vs. Multiple-Stage Interventions in the Management of Subarachnoid Hemorrhage in Patients with Multiple Intracranial Aneurysms.Journal of clinical medicine · 2025Article
- Temporal muscle thickness as a feasible sarcopenia marker and outcome predictor after aneurysmal subarachnoid hemorrhage.Acta neurochirurgica · 2025Article
- Contribution of an Automatic Algorithm for Quantifying the Volume of Aneurysmal Subarachnoid Hemorrhage to the Evaluation of the Risk of Occurrence of Delayed Cerebral Ischemia: A Cohort Study.Neurocritical care · 2025Observational
- State-of-the-art for automated machine learning predicts outcomes in poor-grade aneurysmal subarachnoid hemorrhage using routinely measured laboratory & radiological parameters: coagulation parameters and liver function as key prognosticators.Neurosurgical review · 2025Article
- A nomogram for predicting prognostic risk factors in individuals with poor grade aneurysmal subarachnoid hemorrhage: a retrospective study.Neurosurgical review · 2025Article
- Prognostic factors in aneurysmal subarachnoid hemorrhage with poor initial clinical grade.Frontiers in neurology · 2025Article
- Code Status Transitions of Patients with Aneurysmal Subarachnoid Hemorrhage in the Intensive Care Unit.Palliative medicine reports · 2025Article
- Threshold hemoglobin level for delayed cerebral ischemia: A single-center retrospective analysis.Heliyon · 2024Article
- Survivorship After Neurocritical Care: A Scoping Review of Outcomes Beyond Physical Status.Neurocritical care · 2024Article
- Textbook Outcomes Among Patients with Aneurysmal Subarachnoid Hemorrhage Following Endovascular Treatment.Neurology and therapy · 2024Article
- Factors affecting 30-day mortality in poor-grade aneurysmal subarachnoid hemorrhage: a 10-year single-center experience.Frontiers in neurology · 2024Article
- Length of Survival, Outcome, and Potential Predictors in Poor-Grade Aneurysmal Subarachnoid Hemorrhage Patients Treated with Microsurgical Clipping.CNS & neurological disorders drug targets · 2024Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPatients with poor-grade aneurysmal subarachnoid hemorrhage (aSAH) often receive delayed or no aneurysm treatment, although recent studies suggest that functional outcome following early aneurysm treatment has improved. We aimed to systematically review and meta-analyze early predictors of functional outcome in poor-grade aSAH patients.
methodsWe included studies investigating the association of early predictors and functional outcome in adult patients with confirmed poor-grade aSAH, defined as World Federation of Neurological Surgeons (WFNS) grade or Hunt and Hess (H-H) grade IV-V. Studies had to use multivariable regression analysis to estimate independent predictor effects of favorable functional outcome measured with the Glasgow Outcome Scale or modified Rankin Scale. We calculated pooled adjusted odds ratios (aOR) and 95% confidence intervals (CI) with random effects models.
resultsWe included 27 studies with 3287 patients. The likelihood of favorable outcome increased with WFNS grade or H-H grade IV versus V (aOR 2.9, 95% CI 1.9-4.3), presence of clinical improvement before aneurysm treatment (aOR 3.3, 95% CI 2.0-5.3), and intact pupillary light reflex (aOR 2.9, 95% CI 1.6-5.1), and decreased with older age (aOR 0.7, 95% CI 0.5-1.0, per decade), increasing modified Fisher grade (aOR 0.4, 95% CI 0.3-0.5, per grade), and presence of intracerebral hematoma on admission imaging (aOR 0.4, 95% CI 0.2-0.8).
conclusionsWe present a summary of early predictors of functional outcome in poor-grade aSAH patients that can help to discriminate between patients with favorable and with unfavorable prognosis and may aid in selecting patients for early aneurysm treatment.
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