Evidence map›Paper›PMID 35773558›Full record

ArticleInternational journal of bipolar disorders2022

The association between variability, intensity, and persistence of suicidal ideation and prospective suicidal behavior in the systematic treatment enhancement program for bipolar disorder (STEP-BD) study.

Bartholt Bloomfield-Clagett, Dede K Greenstein, Carlos A Zarate, Elizabeth D Ballard

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Article in International journal of bipolar disorders, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Bartholt Bloomfield-ClagettExperimental Therapeutics & Pathophysiology Branch, National Institute of Mental Health, National Institutes of Health, Building 10, CRC Room 7-5341, 10 Center Drive, MSC 1282, Bethesda, MD, 20892, USA.
Dede K GreensteinExperimental Therapeutics & Pathophysiology Branch, National Institute of Mental Health, National Institutes of Health, Building 10, CRC Room 7-5341, 10 Center Drive, MSC 1282, Bethesda, MD, 20892, USA.
Carlos A ZarateExperimental Therapeutics & Pathophysiology Branch, National Institute of Mental Health, National Institutes of Health, Building 10, CRC Room 7-5341, 10 Center Drive, MSC 1282, Bethesda, MD, 20892, USA.
Elizabeth D BallardExperimental Therapeutics & Pathophysiology Branch, National Institute of Mental Health, National Institutes of Health, Building 10, CRC Room 7-5341, 10 Center Drive, MSC 1282, Bethesda, MD, 20892, USA. elizabeth.ballard@nih.gov.

Funding

Target validation of novel therapeutic agents in mood disordersZIAMH002927 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI ZARATE, CARLOS · 2010 to 2025
$37.1M
Intramural NIH HHS ZIA MH002927National Institute of Mental ZIAMH002927
6 · The paper itself

Abstract

backgroundThis study sought to examine the association between prospective suicidal behavior and variability, intensity, and persistence of suicidal ideation (SI) in bipolar disorder (BD).

methodsData were drawn from the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD), a naturalistic study of 4360 outpatients 15 years or older with BD. In separate models, logistic regressions with suicidal behavior (first attempt or death by suicide) as the outcome variable and SI variability (fluctuating levels of SI over time, measured as ordinal dispersion of SI score), intensity (median SI score over time in study), or persistence (number of visits with reported SI) as the explanatory variables were used to examine the relationship between SI characteristics and odds of future suicidal behavior events.

resultsAfter adjusting for possible confounders, the odds of prospective suicidal behavior were 1.2 times greater per 10% increase in SI variability. SI persistence was not associated with suicidal behavior. For SI intensity, a median SI score of 'rare/fleeting' or 'several days' of SI was not associated with suicidal behavior, but the odds of prospective suicidal behavior were nearly five times greater for participants with the highest observed median SI intensity score of 'nearly every day'.

conclusionsThe findings suggest that, in BD participants, monitoring SI variability may be clinically useful for assessing suicide risk.

Indexed as

Affective instabilityBipolar disorderSuicidal ideationSuicide

Identifiers

PMID35773558
PMCPMC9247121

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