Evidence map›Paper›PMID 35773554›Full record

ReviewEating and weight disorders : EWD2022

The gut microbiome as possible mediator of the beneficial effects of very low calorie ketogenic diet on type 2 diabetes and obesity: a narrative review.

G Defeudis, M Rossini, Y M Khazrai, A M V Pipicelli, G Brucoli, M Veneziano, F Strollo, AMD-SID-SIEDP-Lifestyle Study Group Lazio, A Bellia, O Bitterman and 3 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Eating and weight disorders : EWD, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

G DefeudisUnit of Endocrinology and Diabetes, Department of Medicine, University Campus Bio-Medico di Roma, Rome, Italy. g.defeudis@policlinicocampus.it.ORCID http://orcid.org/0000-0003-2425-5609
M RossiniDiet and Diabetes Unit, ASL RM1, Rome, Italy.
Y M KhazraiUnit of Food Science and Nutrition, Department of Science and Technology for Humans and the Environment, University Campus Bio-Medico di Roma, Rome, Italy.
A M V PipicelliUOC di Nefrologia, Dialisi e Trapianto, Dipartimento di Scienze Mediche e Chirurgiche, Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy.
G BrucoliDiet and Diabetes Unit, ASL RM1, Rome, Italy.
M VenezianoDiet and Diabetes Unit, ASL RM1, Rome, Italy.
F StrolloEndocrinology and Diabetes Unit, IRCCS San Raffaele Pisana, Rome, Italy.
AMD-SID-SIEDP-Lifestyle Study Group Lazio
A Bellia
O Bitterman
D Lauro
D Mora
E Santarelli
Azienda Sanitaria Locale Roma 3 · ITUniversità Campus Bio-Medico · ITIRCCS Ospedale San Raffaele · ITUniversità Cattolica del Sacro Cuore · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Several studies have shown a strong correlation between the different types of diets and gut microbiota composition on glycemia and weight loss. In this direction, low-carbohydrate and ketogenic diets have gained popularity, despite studies published so far leading to controversial results on subjects with diabetes. In this narrative review, firstly, we aimed to analyze the role of very-low-calorie ketogenic diets (VLCKDs) in type 2 diabetes (T2DM) and obesity management. Secondly, in this context, we focused attention on gut microbiota as a function of VLCKD, particularly in T2DM and obesity treatment. Finally, we reported all this evidence to underline the importance of gut microbiota to exalt new nutritional strategies for "tailor-made" management, treatment, and rehabilitation in subjects with T2DM and obesity, even with diabetic complications. In conclusion, this narrative review outlined the beneficial impact of VLCKD on gut microbiota even in subjects with T2DM and obesity, and, despite inner VLCKD short-duration feature allowing no sound-enough provisions for long-term outcomes, witnessed in favor of the short-term safety of VLCKD in those patients.Level of evidence Level V: Opinions of authorities, based on descriptive studies, narrative reviews, clinical experience, or reports of expert committees.

Indexed as

Diabetes Mellitus, Type 2Diet, KetogenicGastrointestinal MicrobiomeBlood GlucoseHumansKetone BodiesObesityBlood GlucoseKetone BodiesDiabetesGut microbiotaObesityRehabilitationVery low-calorie ketogenic dietVLCKDs

Identifiers

PMID35773554
OpenAlexW4283750699

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.