Evidence map›Paper›PMID 35773287›Full record

ReviewNature reviews. Disease primers2022

Cough hypersensitivity and chronic cough.

Kian Fan Chung, Lorcan McGarvey, Woo-Jung Song, Anne B Chang, Kefang Lai, Brendan J Canning, Surinder S Birring, Jaclyn A Smith, Stuart B Mazzone

Registry-linked trialOpen access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nature reviews. Disease primers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07659860 (Does Chronic Cough Lead to Injury and Remodelling of the Lower Airways?), which is not on this map. Cited by 160 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
160citing papers in PubMed, 4 pooled it
39.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07659860 recruitingnot on this map

Does Chronic Cough Lead to Injury and Remodelling of the Lower Airways?

TypeobservationalSponsorMedical University of WarsawRan2022 to 2026Enrolled40ConditionsChronic CoughArmschest computed tomography and bronchoscopy
3 · Its place in the literature

Who cites it

160 citing papers in PubMed, 4 syntheses or guidelines pooled it, 273 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Efficacy and safety of gefapixant for chronic cough: a meta-analysis of randomised controlled trials.European respiratory review : an official journal of the European Respiratory Society · 2023
    Pooled it
  4. Pooled it
  5. Trial
  6. Trial
  7. Trial
  8. Trial
  9. Trial
  10. Trial
  11. Article
  12. Age-Dependent Role of Cough Hypersensitivity in Transition to Refractory Chronic Cough.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2026
    Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Observational
  20. Article

100 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 9 institutions in 5 countries.

Kian Fan ChungExperimental Studies Unit, National Heart & Lung Institute, Imperial College London, London, UK.ORCID 0000-0001-7101-1426
Lorcan McGarveyWellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, UK.
Woo-Jung SongDepartment of Allergy and Clinical Immunology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.ORCID 0000-0002-4630-9922
Anne B ChangAustralian Centre for Health Services Innovation, Queensland's University of Technology and Department of Respiratory and Sleep Medicine, Queensland Children's Hospital, Brisbane, Queensland, Australia.ORCID 0000-0002-1331-3706
Kefang LaiThe First Affiliated Hospital of Guangzhou Medical University, National Center of Respiratory Medicine, National Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, Guangzhou, China.
Brendan J CanningJohns Hopkins Asthma and Allergy Center, Baltimore, MD, USA.
Surinder S BirringCentre for Human & Applied Physiological Sciences, School of Basic & Medical Biosciences, Faculty of Life Sciences & Medicine, King's College London, London, UK.
Jaclyn A SmithDivision of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, University of Manchester, Manchester, UK.
Stuart B MazzoneDepartment of Anatomy and Physiology, University of Melbourne, Victoria, Australia. stuart.mazzone@unimelb.edu.au.ORCID 0000-0001-5270-1333
First Affiliated Hospital of Guangzhou Medical University · CNHarefield Hospital · GBJohns Hopkins University · USKing's College London · GBMenzies School of Health Research · AUQueen's University Belfast · GBThe University of Melbourne · AUUlsan College · KRUniversity of Manchester · GB

Funding

Cholinergic mechanisms involved in transduction of airway defensive reflexesR01HL141251 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI CANNING, BRENDAN J · 2019 to 2021
$1.6M
NHLBI NIH HHS R01 HL141251
6 · The paper itself

Abstract

Chronic cough is globally prevalent across all age groups. This disorder is challenging to treat because many pulmonary and extrapulmonary conditions can present with chronic cough, and cough can also be present without any identifiable underlying cause or be refractory to therapies that improve associated conditions. Most patients with chronic cough have cough hypersensitivity, which is characterized by increased neural responsivity to a range of stimuli that affect the airways and lungs, and other tissues innervated by common nerve supplies. Cough hypersensitivity presents as excessive coughing often in response to relatively innocuous stimuli, causing significant psychophysical morbidity and affecting patients' quality of life. Understanding of the mechanisms that contribute to cough hypersensitivity and excessive coughing in different patient populations and across the lifespan is advancing and has contributed to the development of new therapies for chronic cough in adults. Owing to differences in the pathology, the organs involved and individual patient factors, treatment of chronic cough is progressing towards a personalized approach, and, in the future, novel ways to endotype patients with cough may prove valuable in management.

Indexed as

CoughHypersensitivityAdultChronic DiseaseHumansLungQuality of Life

Identifiers

PMID35773287
PMCPMC9244241
OpenAlexW4283722066

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.