Evidence map›Paper›PMID 35773276›Full record

ArticleScientific reports2022

Spectral organ fingerprints for machine learning-based intraoperative tissue classification with hyperspectral imaging in a porcine model.

Alexander Studier-Fischer, Silvia Seidlitz, Jan Sellner, Berkin Özdemir, Manuel Wiesenfarth, Leonardo Ayala, Jan Odenthal, Samuel Knödler, Karl Friedrich Kowalewski, Caelan Max Haney and 12 more

Abstract read
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Implementation of hyperspectral imaging in a trauma resuscitation room: a randomized controlled trial.Scandinavian journal of trauma, resuscitation and emergency medicine · 2022
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  5. Observational
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  13. Semantic hyperspectral image synthesis for cross-modality knowledge transfer in surgical data science.International journal of computer assisted radiology and surgery · 2025
    Article
  14. Article
  15. Masked image modeling in medical hyperspectral imaging: reconstruction evaluation and downstream tasks.Proceedings of SPIE--the International Society for Optical Engineering · 2025
    Article
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  20. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Alexander Studier-FischerDepartment of General, Visceral, and Transplantation Surgery, Heidelberg University Hospital, Im Neuenheimer Feld 420, 69120, Heidelberg, Germany.ORCID 0000-0001-8682-9300
Silvia SeidlitzDivision of Intelligent Medical Systems, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID 0000-0002-1122-4793
Jan SellnerDivision of Intelligent Medical Systems, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID 0000-0003-4469-8343
Berkin ÖzdemirDepartment of General, Visceral, and Transplantation Surgery, Heidelberg University Hospital, Im Neuenheimer Feld 420, 69120, Heidelberg, Germany.ORCID 0000-0001-8927-4830
Manuel WiesenfarthDivision of Biostatistics, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID 0000-0001-6024-542X
Leonardo AyalaDivision of Intelligent Medical Systems, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID 0000-0002-3574-2085
Jan OdenthalDepartment of General, Visceral, and Transplantation Surgery, Heidelberg University Hospital, Im Neuenheimer Feld 420, 69120, Heidelberg, Germany.ORCID 0000-0003-3612-7401
Samuel KnödlerDepartment of General, Visceral, and Transplantation Surgery, Heidelberg University Hospital, Im Neuenheimer Feld 420, 69120, Heidelberg, Germany.ORCID 0000-0001-5798-8003
Karl Friedrich KowalewskiDepartment of Urology, Medical Faculty of Mannheim, University of Heidelberg, Mannheim, Germany.ORCID 0000-0003-2931-6247
Caelan Max HaneyDepartment of General, Visceral, and Transplantation Surgery, Heidelberg University Hospital, Im Neuenheimer Feld 420, 69120, Heidelberg, Germany.ORCID 0000-0002-4209-9470
Isabella CamplissonDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, USA.ORCID 0000-0001-9653-2789
Maximilian DietrichDepartment of Anesthesiology, Heidelberg University Hospital, Heidelberg, Germany.ORCID 0000-0003-0960-038X
Karsten SchmidtDepartment of Anesthesiology and Intensive Care Medicine, Essen University Hospital, Essen, Germany.ORCID 0000-0001-8373-9406
Gabriel Alexander SalgDepartment of General, Visceral, and Transplantation Surgery, Heidelberg University Hospital, Im Neuenheimer Feld 420, 69120, Heidelberg, Germany.ORCID 0000-0002-3964-3527
Hannes Götz KenngottDepartment of General, Visceral, and Transplantation Surgery, Heidelberg University Hospital, Im Neuenheimer Feld 420, 69120, Heidelberg, Germany.
Tim Julian AdlerDivision of Intelligent Medical Systems, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID 0000-0002-3424-6629
Nicholas SchreckDivision of Biostatistics, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID 0000-0001-9277-4297
Annette Kopp-SchneiderDivision of Biostatistics, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID 0000-0002-1810-0267
Klaus Maier-HeinDivision of Intelligent Medical Systems, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID 0000-0002-6626-2463
Lena Maier-HeinDivision of Intelligent Medical Systems, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID 0000-0003-4910-9368
Beat Peter Müller-StichDepartment of General, Visceral, and Transplantation Surgery, Heidelberg University Hospital, Im Neuenheimer Feld 420, 69120, Heidelberg, Germany.ORCID 0000-0002-8552-8538
Felix NickelDepartment of General, Visceral, and Transplantation Surgery, Heidelberg University Hospital, Im Neuenheimer Feld 420, 69120, Heidelberg, Germany. felix.nickel@med.uni-heidelberg.de.ORCID 0000-0001-6066-8238

Funding

European Research Council 101002198
6 · The paper itself

Abstract

Visual discrimination of tissue during surgery can be challenging since different tissues appear similar to the human eye. Hyperspectral imaging (HSI) removes this limitation by associating each pixel with high-dimensional spectral information. While previous work has shown its general potential to discriminate tissue, clinical translation has been limited due to the method's current lack of robustness and generalizability. Specifically, the scientific community is lacking a comprehensive spectral tissue atlas, and it is unknown whether variability in spectral reflectance is primarily explained by tissue type rather than the recorded individual or specific acquisition conditions. The contribution of this work is threefold: (1) Based on an annotated medical HSI data set (9059 images from 46 pigs), we present a tissue atlas featuring spectral fingerprints of 20 different porcine organs and tissue types. (2) Using the principle of mixed model analysis, we show that the greatest source of variability related to HSI images is the organ under observation. (3) We show that HSI-based fully-automatic tissue differentiation of 20 organ classes with deep neural networks is possible with high accuracy (> 95%). We conclude from our study that automatic tissue discrimination based on HSI data is feasible and could thus aid in intraoperative decisionmaking and pave the way for context-aware computer-assisted surgery systems and autonomous robotics.

Indexed as

Hyperspectral ImagingMachine LearningAnimalsNeural Networks, ComputerSwine

Identifiers

PMID35773276
PMCPMC9247052

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.