Evidence map›Paper›PMID 35773238›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2022

Mammary Leukocyte-Assisted Nanoparticle Transport Enhances Targeted Milk Trace Mineral Delivery.

Jie Cai, Jie Peng, Xinwei Zang, Juan Feng, Ruocheng Li, Peng Ren, Bingzhu Zheng, Jiaying Wang, Juan Wang, Mi Yan and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Identification of nanoparticle infiltration in human breast milk: Chemical profiles and trajectory pathways.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  3. A novel HVEM-Fc recombinant protein for lung cancer immunotherapy.Journal of experimental & clinical cancer research : CR · 2025
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Jie CaiInstitute of Dairy Science, College of Animal Sciences, MOE Key Laboratory of Molecular Animal Nutrition, Zhejiang University, Hangzhou, 310029, P. R. China.
Jie PengSchool of Materials Science and Engineering, State Key Laboratory of Silicon Materials, Institute for Composites Science Innovation, Zhejiang University, Hangzhou, 310027, P. R. China.
Xinwei ZangInstitute of Dairy Science, College of Animal Sciences, MOE Key Laboratory of Molecular Animal Nutrition, Zhejiang University, Hangzhou, 310029, P. R. China.
Juan FengInstitute of Dairy Science, College of Animal Sciences, MOE Key Laboratory of Molecular Animal Nutrition, Zhejiang University, Hangzhou, 310029, P. R. China.
Ruocheng LiInstitute of Dairy Science, College of Animal Sciences, MOE Key Laboratory of Molecular Animal Nutrition, Zhejiang University, Hangzhou, 310029, P. R. China.
Peng RenInstitute of Dairy Science, College of Animal Sciences, MOE Key Laboratory of Molecular Animal Nutrition, Zhejiang University, Hangzhou, 310029, P. R. China.
Bingzhu ZhengSchool of Materials Science and Engineering, State Key Laboratory of Silicon Materials, Institute for Composites Science Innovation, Zhejiang University, Hangzhou, 310027, P. R. China.
Jiaying WangInstitute of Environmental Health, MOE Key Laboratory of Environmental Remediation and Ecosystem Health, College of Environmental & Resource Sciences, Zhejiang University, Hangzhou, 310058, P. R. China.
Juan WangInstitute of Environmental Health, MOE Key Laboratory of Environmental Remediation and Ecosystem Health, College of Environmental & Resource Sciences, Zhejiang University, Hangzhou, 310058, P. R. China.
Mi YanSchool of Materials Science and Engineering, State Key Laboratory of Silicon Materials, Institute for Composites Science Innovation, Zhejiang University, Hangzhou, 310027, P. R. China.
Jianxin LiuInstitute of Dairy Science, College of Animal Sciences, MOE Key Laboratory of Molecular Animal Nutrition, Zhejiang University, Hangzhou, 310029, P. R. China.
Renren DengSchool of Materials Science and Engineering, State Key Laboratory of Silicon Materials, Institute for Composites Science Innovation, Zhejiang University, Hangzhou, 310027, P. R. China.ORCID 0000-0001-8213-6304
Diming WangInstitute of Dairy Science, College of Animal Sciences, MOE Key Laboratory of Molecular Animal Nutrition, Zhejiang University, Hangzhou, 310029, P. R. China.
Institute of Animal Sciences · CNState Key Laboratory of Silicon MaterialsUniversity of Occupational and Environmental Health Japan · JPZhejiang Chinese Medical University · CN

Funding

National Natural Science Foundation of China 31930107National Natural Science Foundation of China T2122003Postdoctoral Science Foundation of China 2021T140589
6 · The paper itself

Abstract

Nanoparticles are applied as versatile platforms for drug/gene delivery in many applications owing to their long-retention and specific targeting properties in living bodies. However, the delivery mechanism and the beneficial effect of nanoparticle-retention in many organisms remain largely uncertain. Here, the transport and metabolism of mineral nanoparticles in mammary gland during lactation are explored. It is shown that maternal intravenous administration of iron oxide nanoparticles (IONPs; diameter: ≈11.0 nm, surface charge: -29.1 mV, surface area: 1.05 m

Indexed as

NanoparticlesTrace ElementsFemaleHumansInfant, NewbornIronLeukocytesMilk, HumanIronTrace Elementsleukocytemammary glandmilkmineral nanoparticlesnutrient delivery

Identifiers

PMID35773238
PMCPMC9475556
OpenAlexW4283749427

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.