Evidence map›Paper›PMID 35772960›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2023

Rong Zhou, Hoon Choi, Jianbo Cao, Austin Pantel, Mamta Gupta, Hsiaoju S Lee, David Mankoff

Open access · bronzeAbstract read
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

  1. Trial
  2. Review
  3. Metabolic Imaging and Molecular Signatures Reveal Metabolic Phenotypes in Recurrent Glioblastoma.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026
    Article
  4. Preclinical Comparison ofJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026
    Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. L-5-[Nuclear medicine and biology
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Rong ZhouDepartment of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania rongzhou@pennmedicine.upenn.edu david.mankoff@pennmedicine.upenn.edu.
Hoon ChoiDepartment of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania.
Jianbo CaoDepartment of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania.
Austin PantelDepartment of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania.
Mamta GuptaDepartment of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania.
Hsiaoju S LeeDepartment of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania.
David MankoffDepartment of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania rongzhou@pennmedicine.upenn.edu david.mankoff@pennmedicine.upenn.edu.
University of Pennsylvania · US

Funding

RESEARCH TRACK RADIOLOGY RESIDENCYT32EB004311 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI Terence P Gade, Misun Hwang · 2005 to 2026
$4.5M
PET Imaging of Glutamine Metabolism and Glutamate Transport to Guide Metabolically Targeted Therapy in Triple-Negative Breast CancerR01CA266285 · NCI · UNIVERSITY OF PENNSYLVANIA · PI DAVID A. MANKOFF, Rong Zhou · 2022 to 2026
$2.6M
Molecular Imaging Markers for Glutaminolysis in Breast CancerR01CA211337 · NCI · UNIVERSITY OF PENNSYLVANIA · PI MANKOFF, DAVID A., ZHOU, RONG · 2017 to 2021
$2.0M
Metabolic Imaging Marker for Triple Negative Breast CancerR21CA198563 · NCI · UNIVERSITY OF PENNSYLVANIA · PI ZHOU, RONG · 2015 to 2016
$383k
NCI NIH HHS R01 CA211337NCI NIH HHS R01 CA266285NCI NIH HHS R21 CA198563NIBIB NIH HHS T32 EB004311
6 · The paper itself

Abstract

Aggressive cancers such as triple-negative breast cancer (TNBC) avidly metabolize glutamine as a feature of their malignant phenotype. The conversion of glutamine to glutamate by the glutaminase enzyme represents the first and rate-limiting step of this pathway and a target for drug development. Indeed, a novel glutaminase inhibitor (GLSi) has been developed and tested in clinical trials but with limited success, suggesting the potential for a biomarker to select patients who could benefit from this novel therapy. Here, we studied a nonmetabolized amino acid analog,

Indexed as

CyclobutanesTriple Negative Breast NeoplasmsAnimalsBiomarkersCarboxylic AcidsGlutaminaseGlutamineHumansKineticsMicePositron-Emission TomographyBiomarkersCarboxylic AcidsCyclobutanesfluciclovine F-18GlutaminaseGlutamine18F-fluciclovine PETCB839distribution volumeglutaminasetriple-negative breast cancer

Identifiers

PMID35772960
PMCPMC9841257
OpenAlexW4283739521

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.