Evidence map›Paper›PMID 35772959›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2022

Improved Tumor Responses with Sequential Targeted α-Particles Followed by Interleukin 2 Immunocytokine Therapies in Treatment of CEA-Positive Breast and Colon Tumors in CEA Transgenic Mice.

Megan Minnix, Maciej Kujawski, Erasmus Poku, Paul J Yazaki, Jeffrey Y Wong, John E Shively

Open access · bronzeAbstract read
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. The molecular blueprint of targeted radionuclide therapy.Nature reviews. Clinical oncology · 2025
    Review
  6. Combination Image-Guided and Antibody-Targeted α-Therapy Before Targeted Immunotherapy for Treatment of Solid Tumors.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025
    Article
  7. Review
  8. Review
  9. Recent advances in the development ofAnalytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2024
    Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Megan MinnixDepartment of Immunology and Theranostics, Riggs Institute of Diabetes and Metabolic Research, Beckman Research Institute of the City of Hope, Duarte, California.
Maciej KujawskiDepartment of Immunology and Theranostics, Riggs Institute of Diabetes and Metabolic Research, Beckman Research Institute of the City of Hope, Duarte, California.
Erasmus PokuRadiopharmacy, Beckman Research Institute of the City of Hope, Duarte, California; and.
Paul J YazakiDepartment of Immunology and Theranostics, Riggs Institute of Diabetes and Metabolic Research, Beckman Research Institute of the City of Hope, Duarte, California.
Jeffrey Y WongDepartment of Radiation Oncology, City of Hope National Medical Center, Duarte, California.
John E ShivelyDepartment of Immunology and Theranostics, Riggs Institute of Diabetes and Metabolic Research, Beckman Research Institute of the City of Hope, Duarte, California; jshively@coh.org.
City of Hope · USBeckman Research InstituteCity Of Hope National Medical Center · US

Funding

Transgenic Mouse FacilityP30CA033572 · NCI · CITY OF HOPE/BECKMAN RESEARCH INSTITUTE · PI STANLEY R. HAMILTON · 1985 to 2026
$86.3M
NCI NIH HHS P30 CA033572
6 · The paper itself

Abstract

Targeted α-therapy (TAT) delivers high-linear-transfer-energy α-particles to tumors with the potential to generate tumor immune responses that may be augmented by antigen-targeted immunotherapy.

Indexed as

Carcinoembryonic AntigenColonic NeoplasmsAnimalsImmunotherapyInterleukin-2MiceMice, Inbred C57BLMice, TransgenicCarcinoembryonic AntigenInterleukin-2breast cancercarcinoembryonic antigencolon cancerradionuclide therapytargeted alpha therapytargeted immunotherapy

Identifiers

PMID35772959
PMCPMC9730924
OpenAlexW4283774589

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.