Evidence map›Paper›PMID 35772956›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2022

Radiotracers to Address Unmet Clinical Needs in Cardiovascular Imaging, Part 2: Inflammation, Fibrosis, Thrombosis, Calcification, and Amyloidosis Imaging.

John C Stendahl, Jennifer M Kwan, Darko Pucar, Mehran M Sadeghi

Open access · bronzeAbstract read
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 24 citations in OpenAlex.

  1. Unveiling the procoagulant state in Alzheimer's disease: A novel PET imaging strategy.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  2. Molecular Imaging of Collagen Turnover in Myocardial Infarction.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026
    Article
  3. Review
  4. Review
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  6. Review
  7. Article
  8. Review
  9. Exploration ofACS omega · 2023
    Article
  10. Review
  11. Beyond perfusion imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

John C StendahlSection of Cardiovascular Medicine, Yale University School of Medicine, New Haven, Connecticut.
Jennifer M KwanSection of Cardiovascular Medicine, Yale University School of Medicine, New Haven, Connecticut.
Darko PucarDepartment of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, Connecticut; and.
Mehran M SadeghiSection of Cardiovascular Medicine, Yale University School of Medicine, New Haven, Connecticut; mehran.sadeghi@yale.edu.
Yale University · USVA Connecticut Healthcare System · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
PET Imaging of MMP Activation in AAA: First in-Human EvaluationR01AG065917 · NIA · YALE UNIVERSITY · PI GROPLER, ROBERT J., SADEGHI, MEHRAN M · 2020 to 2024
$3.3M
Novel Regulators of Calcific Aortic Valve DiseaseR01HL138567 · NHLBI · YALE UNIVERSITY · PI SADEGHI, MEHRAN M · 2017 to 2020
$2.8M
Targeted delivery of nanomedicines to the coronary microvasculature during ex vivo normothermic perfusion of marginal human heartsK08HL155888 · NHLBI · YALE UNIVERSITY · PI John C Stendahl · 2022 to 2026
$811k
Mechanistic studies of disease progression in aortic aneurysmsI01BX004038 · VA · VA CONNECTICUT HEALTHCARE SYSTEM · PI SADEGHI, MEHRAN M · 2019 to 2022
–
BLRD VA I01 BX004038NCATS NIH HHS UL1 TR001863NHLBI NIH HHS K08 HL155888NHLBI NIH HHS R01 HL138567NIA NIH HHS R01 AG065917
6 · The paper itself

Abstract

Cardiovascular imaging is evolving in response to systemwide trends toward molecular characterization and personalized therapies. The development of new radiotracers for PET and SPECT imaging is central to addressing the numerous unmet diagnostic needs that relate to these changes. In this 2-part review, we discuss select radiotracers that may help address key unmet clinical diagnostic needs in cardiovascular medicine. Part 1 examined key technical considerations pertaining to cardiovascular radiotracer development and reviewed emerging radiotracers for perfusion and neuronal imaging. Part 2 covers radiotracers for imaging cardiovascular inflammation, thrombosis, fibrosis, calcification, and amyloidosis. These radiotracers have the potential to address several unmet needs related to the risk stratification of atheroma, detection of thrombi, and the diagnosis, characterization, and risk stratification of cardiomyopathies. In the first section, we discuss radiotracers targeting various aspects of inflammatory responses in pathologies such as myocardial infarction, myocarditis, sarcoidosis, atherosclerosis, and vasculitis. In a subsequent section, we discuss radiotracers for the detection of systemic and device-related thrombi, such as those targeting fibrin (e.g.,

Indexed as

AmyloidosisCalcinosisThrombosisFibrinFibrosisHumansInflammationPositron-Emission TomographyFibrinfibrosisinflammationmolecular imagingradiotracersthrombosis

Identifiers

PMID35772956
PMCPMC9258561
OpenAlexW4283751444

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.