Evidence map›Paper›PMID 35772680›Full record

ArticleJournal of chemical neuroanatomy2022

Single-cell multiplex qPCR evidence for sex-dimorphic glutamate decarboxylase, estrogen receptor, and 5'-AMP-activated protein kinase alpha subunit mRNA expression by ventromedial hypothalamic nucleus GABAergic neurons.

Md Haider Ali, Ayed A Alshamrani, Prabhat R Napit, Karen P Briski

Open access · greenAbstract read
In one paragraph

Article in Journal of chemical neuroanatomy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 21 citations in OpenAlex.

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  3. Genetic adaptations shaping survival, pregnancy, and life at high altitude and sea level.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Md Haider AliSchool of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of Louisiana at Monroe, Monroe, LA 71201, USA.
Ayed A AlshamraniSchool of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of Louisiana at Monroe, Monroe, LA 71201, USA.
Prabhat R NapitSchool of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of Louisiana at Monroe, Monroe, LA 71201, USA.
Karen P BriskiSchool of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of Louisiana at Monroe, Monroe, LA 71201, USA. Electronic address: briski@ulm.edu.
University of Louisiana at Monroe · US

Funding

Estradiol Regulation of Hypothalamic Astrocyte GlycogenR01DK109382 · NIDDK · UNIVERSITY OF LOUISIANA AT MONROE · PI BRISKI, KAREN P · 2016 to 2020
$1.7M
NIDDK NIH HHS R01 DK109382
6 · The paper itself

Abstract

The inhibitory amino acid transmitter γ-aminobutryic acid (GABA) acts within the ventromedial hypothalamus to regulate systemic glucose homeostasis, but the issue of whether this neurochemical signal originates locally or is supplied by afferent innervation remains controversial. Here, combinatory in situ immunocytochemistry/laser-catapult microdissection/single-cell multiplex qPCR techniques were used to investigate the premise that ventromedial hypothalamic nucleus ventrolateral (VMNvl) and/or dorsomedial (VMNdm) division neurons contain mRNAs that encode glutamate decarboxylase (GAD)

Indexed as

AMP-Activated Protein KinasesVentromedial Hypothalamic NucleusAnimalsEstrogen Receptor alphaFemaleGABAergic NeuronsGlutamate DecarboxylaseMaleRatsReceptors, EstrogenRNA, MessengerAMP-Activated Protein KinasesEstrogen Receptor alphaGlutamate DecarboxylaseReceptors, EstrogenRNA, MessengerAMPKEstrogen receptor-alphaGlucokinase regulatory proteinGlutamate decarboxylaseG-protein-coupled estrogen receptor-1Ventromedial hypothalamic nucleus

Identifiers

PMID35772680
PMCPMC9474596
OpenAlexW4283783767

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.