ArticleThe Lancet. Oncology2022
Systemic considerations for the surgical treatment of spinal metastatic disease: a scoping literature review.
Article in The Lancet. Oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Diagnostic accuracy of imaging modalities for detection of spinal metastases: a systematic review and meta-analysis.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025Pooled it
- Assessing the impact of perioperative allogenic blood transfusion in spinal surgery: a comprehensive systematic review, meta-analysis, and meta-regression analysis.Neurosurgical review · 2025Pooled it
- A critical appraisal of clinical practice guidelines on surgical treatments for spinal metastasis.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2024Pooled it
- [Surgical management of spinal metastases].Orthopadie (Heidelberg, Germany) · 2026Review
- Total En Bloc Spondylectomy in Modern Spine Oncology: Selection-Relevant Survival Signals and Treatment Burden in a Single-Center Cohort.Journal of personalized medicine · 2026Article
- Association Between Nutritional Status and Survival in Patients Requiring Treatment for Spinal Metastases.Neurosurgery · 2026Article
- Vertebral metastatic disease: A paradigm shift.Neuro-oncology advances · 2026Review
- Surgical timing, neurological recovery, and survival in spinal metastasis-induced paralysis: a retrospective cohort study with nomogram development.Frontiers in oncology · 2026Article
- Initial management and disposition of metastatic spinal cord compression in the emergency department: a review of the literature.Annals of medicine · 2025Review
- A systematic review on frailty indices utilized in oncologic surgery and radiotherapy for metastatic spine disease: A critical appraisal of components and performance.North American Spine Society journal · 2025Review
- Article
- Maximal feasible resection versus hybrid therapy in spinal metastases: an updated narrative review.World journal of surgical oncology · 2025Review
- Article
- Days at home after treatment of spinal metastases: measurement and validation of a novel patient centered outcome.Journal of neuro-oncology · 2025Article
- The impact of systemic and radiation therapy in patients undergoing spine surgery for metastatic breast cancer: a dual-institution study.Journal of neurosurgery. Spine · 2025Article
- Racial, ethnic, and socioeconomic disparities in clinical trial reporting for metastatic spine tumors: An exploration of North American studies.Neurosurgical review · 2025Review
- A Critical Appraisal of the Application of Frailty and Sarcopenia in the Spinal Oncology Population.Global spine journal · 2025Article
- Overview of Molecular Prognostication for Common Solid Tumor Histologies - What the Surgeon Should Know.Global spine journal · 2025Article
- MRI-based 2.5D deep learning radiomics nomogram for the differentiation of benign versus malignant vertebral compression fractures.Frontiers in oncology · 2025Article
- Differential diagnosis of benign and malignant vertebral compression fractures based on CT radiomics model.Frontiers in oncology · 2025Article
Corrections and comments
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Authors and funding
22 authors.
Funding
Abstract
Systemic assessment is a pillar in the neurological, oncological, mechanical, and systemic (NOMS) decision-making framework for the treatment of patients with spinal metastatic disease. Despite this importance, emerging evidence relating systemic considerations to clinical outcomes following surgery for spinal metastatic disease has not been comprehensively summarised. We aimed to conduct a scoping literature review of this broad topic. We searched MEDLINE, Embase, Scopus, Cochrane Central Register of Controlled Trials, Web of Science, and CINAHL databases from Jan 1, 2000, to July 31, 2021. 61 articles were included, accounting for a total of 22 335 patients. Preoperative systemic variables negatively associated with postoperative clinical outcomes included demographics (eg, older age [>60 years], Black race, male sex, low or elevated body-mass index, and smoking status), medical comorbidities (eg, cardiac, pulmonary, hepatic, renal, endocrine, vascular, and rheumatological), biochemical abnormalities (eg, hypoalbuminaemia, atypical blood cell counts, and elevated C-reactive protein concentration), low muscle mass, generalised motor weakness (American Spinal Cord Injury Association Impairment Scale grade and Frankel grade) and poor ambulation, reduced performance status, and systemic disease burden. This is the first comprehensive scoping review to broadly summarise emerging evidence relevant to the systemic assessment component of the widely used NOMS framework for spinal metastatic disease decision making. Medical, surgical, and radiation oncologists can consider these findings when prognosticating spinal metastatic disease-related surgical outcomes on the basis of patients' systemic condition. These factors might inform a shared decision-making approach with patients and their families.
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