ArticleMolecular cell2022
The mTORC1-SLC4A7 axis stimulates bicarbonate import to enhance de novo nucleotide synthesis.
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Article in Molecular cell, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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0cells of the map it votes in
25citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
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Who cites it
25 citing papers in PubMed, 37 citations in OpenAlex.
- SLC4A7/NBCn1 maintains intracellular pH to support mTORC1 activity and antibody-secreting cell differentiation.Nature communications · 2026Article
- Dynamic control of nucleotide metabolism in physiology and disease.Nature cell biology · 2026Review
- METTL1-mediated mOncogene · 2026Article
- IMP metabolic mechanisms and IMPDH targeting strategies in tumor metabolic reprogramming and therapy (Review).International journal of molecular medicine · 2026Review
- Spectrum and functions of ion channels and transporters in osteoclasts.Bone research · 2026Review
- The oncogenic control of nucleotide synthesis.Oncogenesis · 2026Review
- Membrane-associated Rhes-Slc4a7 complex orchestrates tunneling nanotube formation and mutant Huntingtin spread.Science advances · 2026Article
- SLC4A7 Drives NSCLC Progression and Immune Evasion via pH Dysregulation: Its Targeting Synergizes with Anti-PD-1/L1 Therapy.International journal of biological sciences · 2026Article
- High tide or low tide: the transport and metabolism of mitochondrial nucleotides.The Biochemical journal · 2025Review
- Immunosenescence: signaling pathways, diseases and therapeutic targets.Signal transduction and targeted therapy · 2025Review
- Growth Signaling Networks Orchestrate Cancer Metabolic Networks.Cold Spring Harbor perspectives in medicine · 2024Review
- Article
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- Interplay between mTOR and Purine Metabolism Enzymes and Its Relevant Role in Cancer.International journal of molecular sciences · 2024Review
- The electroneutral NaAmerican journal of physiology. Cell physiology · 2024Article
- Co-Expression Network Analysis Unveiled lncRNA-mRNA Links Correlated to Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitor Resistance and/or Intermediate Epithelial-to-Mesenchymal Transition Phenotypes in a Human Non-Small Cell Lung Cancer Cellular Model System.International journal of molecular sciences · 2024Article
- Increased CONature communications · 2024Article
- Multiple Regulatory Signals and Components in the Modulation of Bicarbonate Transporters.Pharmaceutics · 2024Review
- Regulation of PI3K signaling in cancer metabolism and PI3K-targeting therapy.Translational breast cancer research : a journal focusing on translational research in breast cancer · 2024Review
- A journey into the regulatory secrets of theFrontiers in pharmacology · 2024Review
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Eunus S AliDepartment of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA; Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL 60611, USA.
Anna LipońskaDepartment of Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Brendan P O'HaraDepartment of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA; Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL 60611, USA.
David R AmiciDepartment of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA; Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL 60611, USA.
Michael D TornoDepartment of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA; Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL 60611, USA.
Peng GaoMetabolomics Core Facility, Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL 60611, USA.
John M AsaraMass Spectrometry Core, Beth Israel Deaconess Medical Center, Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
Mee-Ngan F YapDepartment of Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Marc L MendilloDepartment of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA; Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL 60611, USA.
Issam Ben-SahraDepartment of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA; Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL 60611, USA. Electronic address: issam.ben-sahra@northwestern.edu.
Northwestern University · USHarvard University · US
Funding
MEDICAL SCIENTIST TRAINING PROGRAMT32GM008152 · NIGMS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ARDEHALI, HOSSEIN · 1987 to 2021
$24.0MTR&D 7: Cell Specific ProteomicsP41GM108569 · NIGMS · NORTHWESTERN UNIVERSITY · PI KELLEHER, NEIL L · 2015 to 2024
$13.6MRegulation and function of bacterial hibernating 100S ribosomeR01GM121359 · NIGMS · SAINT LOUIS UNIVERSITY · PI YAP, M.-N. FRANCES · 2017 to 2025
$3.2MEvolution and consequences of multidrug resistant ribosomeR01AI150986 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI YAP, M.-N. FRANCES · 2020 to 2024
$2.3MRegulation of de novo purine synthesis by the MAPK/ERK pathwayR01GM135587 · NIGMS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI BEN-SAHRA, ISSAM · 2020 to 2024
$1.7MControl of RNA methylation by growth signals through the mTORC1 pathwayR01GM143334 · NIGMS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI BEN-SAHRA, ISSAM · 2021 to 2024
$1.3MElucidating the Role of C16orf72 in the Cellular Stress Response NetworkF30CA264513 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI AMICI, DAVID RUSSELL · 2021 to 2025
$222kNCI NIH HHS F30 CA264513NIAID NIH HHS R01 AI150986NIGMS NIH HHS P41 GM108569NIGMS NIH HHS R01 GM121359NIGMS NIH HHS R01 GM135587NIGMS NIH HHS R01 GM143334NIGMS NIH HHS T32 GM008152
Abstract
Bicarbonate (HCO
Indexed as
BicarbonatesMechanistic Target of Rapamycin Complex 1NucleotidesSodium-Bicarbonate SymportersHumansPhosphorylationBicarbonatesMechanistic Target of Rapamycin Complex 1NucleotidesSLC4A7 protein, humanSodium-Bicarbonate Symportersbicarbonate metabolismmTOR signalingpurine metabolismpyrimidine metabolismSLC4A7/NBCn1
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.