ArticleScience (New York, N.Y.)2022
Synthetic regulatory reconstitution reveals principles of mammalian
Abstract read
In one paragraph
Article in Science (New York, N.Y.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed.
- Highly multiplexed mammalian metabolic engineering with a shotgun approach.Nature biotechnology · 2026Article
- Multichannel genomic recording of biological information with ENGRAM.Nature protocols · 2026Review
- Synthetic Regulatory Genomics.Annual review of genomics and human genetics · 2026Review
- One Yeast, Sixteen Synthetic Chromosomes, Infinite Possibilities.Yeast (Chichester, England) · 2026Review
- Synthetic rewriting of the IGH locus.Cell genomics · 2026Article
- STRAIGHT-IN Dual: a platform for dual single-copy integrations of DNA payloads and gene circuits into human induced pluripotent stem cells.Nature biomedical engineering · 2026Article
- Automated linear DNA assembly of A. thaliana's chloroplast and mitochondrial genome.Nucleic acids research · 2026Article
- Improved vector toolkit for genome writing in mammalian cells.bioRxiv : the preprint server for biology · 2026Article
- Programmable nanobody circuits for cell selection.bioRxiv : the preprint server for biology · 2026Article
- Article
- Review
- Synthetic rewriting technologies in mammalian cells.Nature communications · 2026Review
- Genome writing and Targeted Delivery of thebioRxiv : the preprint server for biology · 2026Article
- A parts list of promoters and gRNA scaffolds for mammalian genome engineering and molecular recording.Nature biotechnology · 2025Article
- Iterative improvement of deep learning models using synthetic regulatory genomics.Genome research · 2025Article
- Human Genome REWRITE for Off-the-Shelf Stem Cells Reveals an "Epigenetic Ghost".bioRxiv : the preprint server for biology · 2025Article
- Synthetic collinearization of a chromosome segment enables genetic dissection of incompatibility between distant genera.bioRxiv : the preprint server for biology · 2025Article
- STRAIGHT-IN Dual: a platform for dual, single-copy integrations of DNA payloads and gene circuits into human induced pluripotent stem cell.bioRxiv : the preprint server for biology · 2025Article
- De novo assembly and delivery of synthetic megabase-scale human DNA into mouse early embryos.Nature methods · 2025Article
- The design and engineering of synthetic genomes.Nature reviews. Genetics · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors.
Sudarshan Pinglay *Institute for Systems Genetics, NYU Langone Health, New York, NY 10016, USA.ORCID 0000-0002-8781-1476
Milica Bulajić *Department of Biology, New York University, New York, NY 10003, USA.ORCID 0000-0001-8592-0022
Dylan P RaheDepartment of Biology, New York University, New York, NY 10003, USA.ORCID 0000-0001-7727-5561
Emily HuangInstitute for Systems Genetics, NYU Langone Health, New York, NY 10016, USA.ORCID 0000-0002-9558-7814
Ran BroshInstitute for Systems Genetics, NYU Langone Health, New York, NY 10016, USA.ORCID 0000-0001-9714-8623
Nicholas E MamrakInstitute for Systems Genetics, NYU Langone Health, New York, NY 10016, USA.
Benjamin R KingInstitute for Systems Genetics, NYU Langone Health, New York, NY 10016, USA.
Sergei GermanInstitute for Systems Genetics, NYU Langone Health, New York, NY 10016, USA.
John A CadleyInstitute for Systems Genetics, NYU Langone Health, New York, NY 10016, USA.ORCID 0000-0002-3739-4838
Lila RieberCenter for Eukaryotic Gene Regulation, Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA 16802, USA.
Nicole EasoInstitute for Systems Genetics, NYU Langone Health, New York, NY 10016, USA.ORCID 0000-0002-9919-3695
Timothée LionnetInstitute for Systems Genetics, NYU Langone Health, New York, NY 10016, USA.ORCID 0000-0003-1508-0202
Shaun MahonyCenter for Eukaryotic Gene Regulation, Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA 16802, USA.ORCID 0000-0002-2641-1807
Matthew T MauranoInstitute for Systems Genetics, NYU Langone Health, New York, NY 10016, USA.ORCID 0000-0002-2218-8628
Liam J HoltInstitute for Systems Genetics, NYU Langone Health, New York, NY 10016, USA.ORCID 0000-0002-4002-0861
Esteban O MazzoniDepartment of Biology, New York University, New York, NY 10003, USA.ORCID 0000-0001-8994-681X
Jef D BoekeInstitute for Systems Genetics, NYU Langone Health, New York, NY 10016, USA.ORCID 0000-0001-5322-4946
Funding
Supplement for Center for Synthetic Regulatory Genomics: Building CACNA1C alleles associated with Neuropsychiatric DisordersRM1HG009491 · NHGRI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Jef D BOEKE · 2018 to 2026
$20.9MUnderstanding CTCF Boundaries Controlling Hox Gene ExpressionR01NS100897 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Esteban Orlando Mazzoni, DANNY REINBERG · 2018 to 2026
$4.1MCancer under pressure: Mechanisms of adaptation to compressive stressR37CA240765 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI HOLT, LIAM J · 2019 to 2025
$3.2MDissecting CEBPB Function with Synthetic Biology and ImagingR01AG075272 · NIA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Timothee Lionnet · 2022 to 2026
$3.2MUnderstanding the predeterminants of transcription factor regulatory activityR35GM144135 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI Shaun Aengus Mahony · 2022 to 2026
$2.4MSynthetic HoxA to dissect transcriptional regulatory logic - TRFRR01GM138876 · NIGMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI MAZZONI, ESTEBAN ORLANDO · 2021 to 2024
$2.4MVisualizing and manipulating chromatin dynamics in living cellsR01GM127538 · NIGMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI LIONNET, TIMOTHEE · 2018 to 2021
$2.0MSpatially resolved single-cell patterns of drug-resistant ovarian cancersF32CA239394 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI KING, BENJAMIN ROBERT · 2019 to 2021
$156kNCI NIH HHS F32 CA239394NCI NIH HHS R37 CA240765NHGRI NIH HHS RM1 HG009491NIA NIH HHS R01 AG075272NIGMS NIH HHS R01 GM127538NIGMS NIH HHS R01 GM138876NIGMS NIH HHS R35 GM144135NINDS NIH HHS R01 NS100897
Abstract
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Indexed as
Body PatterningGene Expression Regulation, DevelopmentalGenes, HomeoboxHomeodomain ProteinsAnimalsEnhancer Elements, GeneticGenomeMiceRatsTranscription, GeneticHomeodomain Proteins
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.