ArticleJAMA network open2022
Accuracy of Chest Computed Tomography in Distinguishing Cystic Pleuropulmonary Blastoma From Benign Congenital Lung Malformations in Children.
Article in JAMA network open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 16 citations in OpenAlex.
- Article
- Giant Pulmonary Hamartoma in a Child: A Case Report.Journal of paediatrics and child health · 2026Article
- Pleuropulmonary blastoma and the challenge of distinguishing the cystic form (type I) from other congenital lung malformations.Pediatric radiology · 2026Review
- Rising detection of congenital pulmonary airway malformations and a pragmatic institutional algorithm: a four-patient thoracoscopic case series.Journal of surgical case reports · 2026Article
- Recurrent pleuropulmonary blastoma type III initially misclassified as embryonal rhabdomyosarcoma on limited biopsy: a case report with pathogenic DICER1 variant.Frontiers in pediatrics · 2026Article
- Large pleuropulmonary blastoma mimicking congenital pulmonary airway malformation in an infant: A case report.Respiratory medicine case reports · 2026Article
- Article
- GPC3: a novel mutated gene in pleuropulmonary blastoma.Discover oncology · 2025Article
- Type III pleuropulmonary blastoma: A case report.Oncology letters · 2025Article
- Interobserver agreement of an ED PoCUS video training dataset of normal appendix and appendicitis in children.The ultrasound journal · 2024Article
- Article
- Patient Characteristics, Treatment, and Survival in Pleuropulmonary Blastoma: An Analysis from the National Cancer Database.Children (Basel, Switzerland) · 2024Article
- Spontaneous pneumothorax or no pneumothorax at all?Breathe (Sheffield, England) · 2023Article
- Challenges in DICER1-Associated Lung Disease.Journal of clinical medicine · 2023Review
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Authors and funding
27 authors at 19 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Importance: The ability of computed tomography (CT) to distinguish between benign congenital lung malformations and malignant cystic pleuropulmonary blastomas (PPBs) is unclear. Objective: To assess whether chest CT can detect malignant tumors among postnatally detected lung lesions in children. Design, Setting, and Participants: This retrospective multicenter case-control study used a consortium database of 521 pathologically confirmed primary lung lesions from January 1, 2009, through December 31, 2015, to assess diagnostic accuracy. Preoperative CT scans of children with cystic PPB (cases) were selected and age-matched with CT scans from patients with postnatally detected congenital lung malformations (controls). Statistical analysis was performed from January 18 to September 6, 2020. Preoperative CT scans were interpreted independently by 9 experienced pediatric radiologists in a blinded fashion and analyzed from January 24, 2019, to September 6, 2020. Main Outcomes and Measures: Accuracy, sensitivity, and specificity of CT in correctly identifying children with malignant tumors. Results: Among 477 CT scans identified (282 boys [59%]; median age at CT, 3.6 months [IQR, 1.2-7.2 months]; median age at resection, 6.9 months [IQR, 4.2-12.8 months]), 40 cases were extensively reviewed; 9 cases (23%) had pathologically confirmed cystic PPB. The median age at CT was 7.3 months (IQR, 2.9-22.4 months), and median age at resection was 8.7 months (IQR, 5.0-24.4 months). The sensitivity of CT for detecting PPB was 58%, and the specificity was 83%. High suspicion for malignancy correlated with PPB pathology (odds ratio, 13.5; 95% CI, 2.7-67.3; P = .002). There was poor interrater reliability (κ = 0.36 [range, 0.06-0.64]; P < .001) and no significant difference in specific imaging characteristics between PPB and benign cystic lesions. The overall accuracy rate for distinguishing benign vs malignant lesions was 81%. Conclusions and Relevance: This study suggests that chest CT, the current criterion standard imaging modality to assess the lung parenchyma, may not accurately and reliably distinguish PPB from benign congenital lung malformations in children. In any cystic lung lesion without a prenatal diagnosis, operative management to confirm pathologic diagnosis is warranted.
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