Evidence map›Paper›PMID 35771569›Full record

Trial reportAmerican journal of respiratory and critical care medicine2022

A Phase IIb Randomized Clinical Study of an Anti-α

Ganesh Raghu, Majd Mouded, Daniel C Chambers, Fernando J Martinez, Luca Richeldi, Lisa H Lancaster, Mark J Hamblin, Kevin F Gibson, Ivan O Rosas, Antje Prasse and 11 more

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in American journal of respiratory and critical care medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed, 3 pooled it
13.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 3 syntheses or guidelines pooled it, 95 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Bexotegrast in Patients with Idiopathic Pulmonary Fibrosis: The INTEGRIS-IPF Clinical Trial.American journal of respiratory and critical care medicine · 2024
    Trial
  6. Trial
  7. Randomized Phase IIa Clinical Study of an Anti-αAmerican journal of respiratory and critical care medicine · 2022
    Trial
  8. Article
  9. Review
  10. Article
  11. The emerging role of integrin signaling in pulmonary vascular disease.American journal of physiology. Lung cellular and molecular physiology · 2026
    Review
  12. Review
  13. Article
  14. Article
  15. Review
  16. Monocyte-mediated mechanisms in idiopathic pulmonary fibrosis: opportunities for early intervention.Apoptosis : an international journal on programmed cell death · 2026
    Review
  17. Review
  18. Collagen in Fibrotic Diseases.Sub-cellular biochemistry · 2026
    Review
  19. Review
  20. The importance of mechanical forces in chronic respiratory diseases.European respiratory review : an official journal of the European Respiratory Society · 2026
    Review

3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

21 authors at 11 institutions in 4 countries.

Ganesh RaghuDivision of Pulmonary, Critical Care and Sleep Medicine, Center for Interstitial Lung Diseases, University of Washington Medical Center, Seattle, Washington.
Majd MoudedBiogen Inc., Cambridge, Massachusetts.
Daniel C ChambersQueensland Lung Transplant Program, The Prince Charles Hospital, Brisbane, Australia.
Fernando J MartinezDepartment of Pulmonary Critical Care Medicine, New York-Presbyterian Hospital, Weill Cornell Medical Center, New York, New York.
Luca RicheldiFondazione Policlinico A. Gemelli, Istituto di Ricovero e Cura a Carattere Scientifico, Università Cattolica del Sacro Cuore, Rome, Italy.
Lisa H LancasterDepartment of Medicine, Vanderbilt University, Nashville, Tennessee.
Mark J HamblinPulmonary and Critical Care Medicine, University of Kansas Medical Center, Kansas City, Kansas.
Kevin F GibsonDivision of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Ivan O RosasDivision of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, Massachusetts.
Antje PrasseDepartment of Pneumology, Medical School of Hannover, Hannover, Germany; and.
Guolin ZhaoBiogen Inc., Cambridge, Massachusetts.
Michael SerenkoBiogen Inc., Cambridge, Massachusetts.
Natasha NovikovBiogen Inc., Cambridge, Massachusetts.
Amy McCurleyBiogen Inc., Cambridge, Massachusetts.
Prashant BansalBiogen Inc., Cambridge, Massachusetts.
Christopher StebbinsBiogen Inc., Cambridge, Massachusetts.
Million ArefayeneBiogen Inc., Cambridge, Massachusetts.
Stella IbebunjoBiogen Inc., Cambridge, Massachusetts.
Shelia M VioletteBiogen Inc., Cambridge, Massachusetts.
Diana GallagherBiogen Inc., Cambridge, Massachusetts.
Jürgen BehrDepartment of Medicine V, University Hospital, LMU Munich, German Center for Lung Research (DZL), Munich, Germany.
Biogen (United States) · USBrigham and Women's Hospital · USGerman Center for Lung Research · DEMedizinische Hochschule Hannover · DENewYork–Presbyterian Hospital · USThe University of Queensland · AUUniversità Cattolica del Sacro Cuore · ITUniversity of Kansas Medical Center · USUniversity of Pittsburgh · USUniversity of Washington Medical Center · USVanderbilt University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Idiopathic Pulmonary FibrosisAntibodies, MonoclonalDouble-Blind MethodHumansImmunoglobulin GTreatment OutcomeAntibodies, MonoclonalImmunoglobulin Ganti-αvβ6 IgG1 monoclonal antibodyidiopathic pulmonary fibrosisrandomized clinical trialsafetytreatment efficacy

Identifiers

PMID35771569
OpenAlexW4283747664

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.