Evidence map›Paper›PMID 35771510›Full record

ArticleBehavioral neuroscience2022

Chemogenetic inhibition of corticotropin-releasing factor neurons in the central amygdala alters binge-like ethanol consumption in male mice.

S Alex Marshall, Stacey L Robinson, Suzahn E Ebert, Michel A Companion, Todd E Thiele

Open access · hybridAbstract read
In one paragraph

Article in Behavioral neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Mouse parasubthalamicbioRxiv : the preprint server for biology · 2024
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

S Alex MarshallDepartment of Psychology & Neuroscience.ORCID 0000-0002-3425-7897
Stacey L RobinsonDepartment of Psychology & Neuroscience.
Suzahn E EbertDepartment of Psychology & Neuroscience.
Michel A CompanionDepartment of Psychology & Neuroscience.
Todd E ThieleDepartment of Psychology & Neuroscience.

Funding

UNC ARC Information/Dissemination CoreP60AA011605 · NIAAA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Clyde W Hodge · 2003 to 2026
$46.3M
SEEDING POSTDOCTORAL INNOVATORS IN RESEARCH &EDUCATIONK12GM000678 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DONALD T LYSLE, Kathryn Joanna Reissner · 1999 to 2026
$30.9M
Training on Research in Drug AbuseT32DA007244 · NIDA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Regina M Carelli · 1990 to 2026
$7.6M
MOLECULAR AND CELLULAR PATHOGENESIS IN ALCOHOLISMP50AA011605 · NIAAA · UNIVERSITY OF NORTH CAROLINA CHAPEL HILL · PI BREESE, GEORGE R · 1998 to 2002
$4.9M
Neuropeptide Y: Role in Ethanol Intake and SensitivityR01AA013573 · NIAAA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI THIELE, TODD ERIC · 2001 to 2018
$3.8M
The role of corticotropin releasing factor in binge-like ethanol drinkingR01AA022048 · NIAAA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Thomas L. Kash, TODD Eric THIELE · 2013 to 2026
$3.2M
The role of brainstem norepinephrine in binge alcohol drinking and taste aversionR01AA025809 · NIAAA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI TODD Eric THIELE, Montserrat Navarro Thiele · 2018 to 2026
$3.1M
Neuropeptide Y: Role in Ethanol Intake and SensitivityR37AA013573 · NIAAA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI TODD Eric THIELE · 2019 to 2026
$3.0M
Melanocortin Neuropeptides &Ethanol IntakeR01AA015148 · NIAAA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI THIELE, TODD ERIC · 2005 to 2014
$2.5M
The Functional Implications of Astrocytic GPCR-signaling on Alcohol AbuseSC1GM139696 · NIGMS · NORTH CAROLINA CENTRAL UNIVERSITY · PI MARSHALL, SIMON ALEXANDER · 2021 to 2024
$1.5M
Feeding the STEM Pipeline with Neuroscientist Trained at an HBCUR25MH129791 · NIMH · NORTH CAROLINA CENTRAL UNIVERSITY · PI Gregory Jay Cole, Wendy Heck Grillo · 2022 to 2026
$1.1M
The role of central amygdala somatostatin signaling in binge ethanol drinkingK99AA028268 · NIAAA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ROBINSON, STACEY · 2021 to 2022
$248k
NIAAA NIH HHS F31 AA027134NIAAA NIH HHS F32 AA021611NIAAA NIH HHS F32 AA025811NIAAA NIH HHS K99 AA028268NIAAA NIH HHS P50 AA011605NIAAA NIH HHS P60 AA011605NIAAA NIH HHS R01 AA013573NIAAA NIH HHS R01 AA015148NIAAA NIH HHS R01 AA022048NIAAA NIH HHS R01 AA025809NIAAA NIH HHS R37 AA013573NIDA NIH HHS T32 DA007244NIGMS NIH HHS K12 GM000678NIGMS NIH HHS SC1 GM139696NIH HHSNIMH NIH HHS R25 MH129791
6 · The paper itself

Abstract

Repetitive bouts of binge drinking can lead to neuroplastic events that alter ethanol's pharmacologic effects and perpetuate excessive consumption. The corticotropin-releasing factor (CRF) system is an example of ethanol-induced neuroadaptations that drive excessive ethanol consumption. Our laboratory has previously shown that CRF antagonist, when infused into the central amygdala (CeA), reduces binge-like ethanol consumption. The present study extends this research by assessing the effects of silencing CRF-producing neurons in CeA on binge-like ethanol drinking stemming from "Drinking in the Dark" (DID) procedures. CRF-ires-Cre mice underwent surgery to infuse G

Indexed as

Central Amygdaloid NucleusCorticotropin-Releasing HormoneAnimalsEthanolMaleMiceMice, Inbred C57BLNeuronsCorticotropin-Releasing HormoneEthanol

Identifiers

PMID35771510
PMCPMC9671851
OpenAlexW4283752758

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.