Evidence map›Paper›PMID 35771497›Full record

ArticleDevelopmental psychology2022

An in-laboratory stressor reveals unique genetic variation in child cortisol output.

Laurel Raffington, Margherita Malanchini, Andrew D Grotzinger, James W Madole, Laura E Engelhardt, Aditi Sabhlok, Cherry Youn, Megan W Patterson, K Paige Harden, Elliot M Tucker-Drob

Abstract read
In one paragraph

Article in Developmental psychology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Laurel RaffingtonDepartment of Psychology.ORCID 0000-0002-0144-5605
Margherita MalanchiniDepartment of Psychology.ORCID 0000-0002-7257-6119
Andrew D GrotzingerDepartment of Psychology.
James W MadoleDepartment of Psychology.ORCID 0000-0002-2301-0004
Laura E EngelhardtDepartment of Psychology.ORCID 0000-0001-7254-5702
Aditi SabhlokDepartment of Psychology.ORCID 0000-0001-6604-1698
Cherry YounDepartment of Psychology.ORCID 0000-0001-5445-6802
Megan W PattersonDepartment of Psychology.ORCID 0000-0002-8299-2706
K Paige HardenDepartment of Psychology.ORCID 0000-0002-1557-6737
Elliot M Tucker-DrobDepartment of Psychology.ORCID 0000-0001-5599-6237

Funding

Population Research CenterR24HD042849 · NICHD · UNIVERSITY OF TEXAS AUSTIN · PI HAYWARD, MARK D. · 2002 to 2016
$8.4M
Program Development and Pilot CoreP30AG066614 · NIA · UNIVERSITY OF TEXAS AT AUSTIN · PI KAREN L FINGERMAN · 2020 to 2026
$5.2M
Scientific & Technical CoreP2CHD042849 · NICHD · UNIVERSITY OF TEXAS AT AUSTIN · PI MARK D. HAYWARD · 2017 to 2026
$5.2M
Cortisol, Socioeconomic Status, and Genetic Influences on Cognitive DevelopmentR01HD083613 · NICHD · UNIVERSITY OF TEXAS AT AUSTIN · PI TUCKER-DROB, ELLIOT MAX · 2016 to 2020
$3.0M
Environmental, Genetic, and Epigenetic Mechanisms for Hormonal ChangeR01HD092548 · NICHD · UNIVERSITY OF TEXAS AT AUSTIN · PI HARDEN, KATHRYN PAIGE · 2019 to 2023
$3.0M
German Research Foundation (DFG)Jacobs FoundationNIA NIH HHS P30 AG066614NICHD NIH HHS P2C HD042849NICHD NIH HHS R01 HD083613NICHD NIH HHS R01 HD092548NICHD NIH HHS R24 HD042849NIH HHS
6 · The paper itself

Abstract

Dysregulation of biological stress response, as measured by cortisol output, has been a primary candidate mechanism for how social experiences become biologically embedded. Cortisol is the primary output of the hypothalamic pituitary adrenal (HPA) axis. Cortisol levels vary systematically across the day and change in response to both sudden, acute stress experiences as well as prolonged exposure to environmental stress. Using data from 8- to 15-year-old twins in the Texas Twin Project, we investigate the extent to which genetic influences are shared across different measures of cortisol output: chronic cortisol accumulations in hair (

Indexed as

HydrocortisoneSalivaGenetic VariationHumansHypothalamo-Hypophyseal SystemPituitary-Adrenal SystemStress, PsychologicalHydrocortisone

Identifiers

PMID35771497
PMCPMC9878466

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.