Structural connectome-based prediction of trait anxiety.

Neurobiological research on anxiety has shown that trait-anxious individuals may be characterized by weaker structural connectivity of the amygdala-prefrontal circuitry, representing a reduced capacity for efficient communication between the two brain regions. However, comparison of available studies has been inconsistent, possibly related to factors such as aging that influences both trait anxiety and structural connectivity of the brain. To help clarify the nature of brain-anxiety relationship, we applied a connectome-based predictive modeling framework on 148 diffusion-weighted imaging data from the Leipzig Study for Mind-Body Emotion Interactions dataset and identified multivariate patterns of whole-brain structural connectivity that predicted trait anxiety. Results showed that networks predictive of trait anxiety differed across age groups. Specifically, an isolated negative network, which shared overlapping features with the amygdala-prefrontal circuitry, was found in younger adults (20-30 years of age), whereas a widespread positive network highlighted by frontotemporal and frontolimbic connectivity was identified when both younger and older adults (20-80 years of age) were examined. No predictive network was observed when only older adults (30-80 years of age) were considered. Our findings highlight an important age-dependent effect on the structural connectome-based prediction of trait anxiety, supporting ongoing efforts to develop potential neural biomarkers of anxiety.