Evidence map›Paper›PMID 35771368›Full record

ArticleAnnals of surgical oncology2022

Clinicopathological Characteristics Predicting Further Recurrence and Survival Following Resection of In-Transit Melanoma Metastases.

Anna K Lawless, David J Coker, Serigne N Lo, Tasnia Ahmed, Richard A Scolyer, Sydney Ch'ng, Omgo E Nieweg, Kerwin Shannon, Andrew Spillane, Jonathan R Stretch and 2 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of surgical oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Anna K LawlessMelanoma Institute Australia, The University of Sydney, Sydney, NSW, Australia.ORCID http://orcid.org/0000-0003-3811-2916
David J CokerMelanoma Institute Australia, The University of Sydney, Sydney, NSW, Australia.
Serigne N LoMelanoma Institute Australia, The University of Sydney, Sydney, NSW, Australia.
Tasnia AhmedMelanoma Institute Australia, The University of Sydney, Sydney, NSW, Australia.
Richard A ScolyerMelanoma Institute Australia, The University of Sydney, Sydney, NSW, Australia.
Sydney Ch'ngMelanoma Institute Australia, The University of Sydney, Sydney, NSW, Australia.
Omgo E NiewegMelanoma Institute Australia, The University of Sydney, Sydney, NSW, Australia.
Kerwin ShannonMelanoma Institute Australia, The University of Sydney, Sydney, NSW, Australia.
Andrew SpillaneMelanoma Institute Australia, The University of Sydney, Sydney, NSW, Australia.
Jonathan R StretchMelanoma Institute Australia, The University of Sydney, Sydney, NSW, Australia.
John F ThompsonMelanoma Institute Australia, The University of Sydney, Sydney, NSW, Australia.
Robyn P M SawMelanoma Institute Australia, The University of Sydney, Sydney, NSW, Australia. robyn.saw@melanoma.org.au.
The University of Sydney · AU

Funding

Melanoma Research Alliance 700455National Health and Medical Research Council APP1093017National Health and Medical Research Council APP1141295
6 · The paper itself

Abstract

backgroundIn-transit metastases (ITMs) affect approximately 4% of patients with cutaneous melanoma. This study sought to identify clinical and pathological characteristics that predict further recurrence and survival following resection of ITMs. PATIENTS AND

methodsPatients (n = 573) who underwent surgical resection of their first presentation of ITM following previous surgical treatment of an American Joint Committee on Cancer (AJCC) stage I-II melanoma between 1969 and 2017 were identified from an institutional database. Clinicopathological predictors of patterns of recurrence and survival following ITM resection were sought.

resultsThe median time of ITM development was 2.4 years after primary melanoma resection. ITMs were most frequently located on the lower limb (51.0%). The most common melanoma subtype associated with ITM development was nodular melanoma (44.1%). After surgical resection of a first ITM, 65.4% of patients experienced recurrent disease. Most recurrences were locoregional (44.7%), with distant metastasis occurring in 23.9% of patients. Lower limb ITMs were more frequently associated with subsequent ITMs [odds ratio (OR) 2.41, p = 0.0002], and the lowest risk of distant metastasis (p < 0.0001) compared with other primary sites. Primary melanomas and ITM on head and neck, as well as the presence of ulceration, were associated with worse survival.

conclusionsRecurrence after surgical resection of a first ITM was common. Patterns of recurrence differed according to anatomical site; further ITM recurrences were more likely for lower limb ITMs, which were also associated with longer distant recurrence-free survival. Distant metastasis was more common for ITM on the head and neck, with worse survival.

Indexed as

MelanomaSkin NeoplasmsCutaneous Malignant MelanomaHumansLymphatic MetastasisNeoplasm Recurrence, Local

Identifiers

PMID35771368
PMCPMC9492704
OpenAlexW4283752195

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.