ArticleEuropean radiology2022
The MRI enhancement ratio and plaque steepness may be more accurate for predicting recurrent ischemic cerebrovascular events in patients with intracranial atherosclerosis.
Article in European radiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Intracranial atherosclerotic plaque features on vessel wall imaging predict first ever and recurrence of stroke: a meta-analysis.European radiology · 2025Pooled it
- High-risk plaque characteristics associated with recurrent stroke in patients with intracranial stenosis: a systematic review and meta-analysis.Journal of neurology · 2025Pooled it
- The Tortuosity of Middle Cerebral Artery is Associated with Ipsilateral Recurrence of Ischemic Events.Journal of atherosclerosis and thrombosis · 2026Article
- Intracranial Plaque Characteristics and Extracranial Carotid Plaque-RADS Associated With Stroke Recurrence: A High-Resolution Vessel Wall Imaging Study.Journal of magnetic resonance imaging : JMRI · 2026Article
- Expert consensus on intracranial vessel wall MRI in cerebrovascular disease: Society for Magnetic Resonance Angiography recommendations.European radiology · 2026Review
- The effects of moderate-dose statin therapy on intracranial plaques with mild to moderate stenosis: a high-resolution MR vessel wall imaging study.European radiology · 2026Article
- Differentiated risk factors for stroke recurrence in anterior versus posterior circulation intracranial atherosclerosis: A high-resolution vessel wall imaging study.Neuroimage. Reports · 2026Article
- High-resolution MRI-based Radiomics and Machine Learning for Identification of Middle Cerebral Artery Vulnerable PlaquesCurrent medical imaging · 2026Article
- Atherosclerotic plaque evolution predicts cerebral ischemic events in patients with intracranial atherosclerosis: a multicentre longitudinal study using high-resolution MRI.European radiology · 2025Article
- MRI-based habitat radiomics combined with vision transformer for identifying vulnerable intracranial atherosclerotic plaques and predicting stroke events: a multicenter, retrospective study.EClinicalMedicine · 2025Article
- Differences in plaque curvature in middle cerebral artery stenosis between acute stroke and non-acute stroke.Quantitative imaging in medicine and surgery · 2025Article
- Evaluation of Intensive Statins and Proprotein Convertase Subtilisin/Kexin Type 9 Inhibitors on Intracranial Artery Plaque Stability: A Prospective Single-Arm Study.Journal of the American Heart Association · 2025Article
- Distinguishing stroke from transient ischemic attack using plaque characteristics and arterial transit artifacts.Frontiers in neurology · 2025Article
- Assessment of paclitaxel drug-coated balloon angioplasty for intracranial atherosclerotic disease based on high-resolution vessel wall magnetic resonance imaging.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2024Article
- Delayed Enhancement of Intracranial Atherosclerotic Plaque Can Better Differentiate Culprit Lesions: A Multiphase Contrast-Enhanced Vessel Wall MRI Study.AJNR. American journal of neuroradiology · 2024Article
- HR-MRI-based nomogram network calculator to predict stroke recurrence in high-risk non-disabling ischemic cerebrovascular events patients.Frontiers in neurology · 2024Article
- Hemodynamics combined with inflammatory indicators exploring relationships between ischemic stroke and symptomatic middle cerebral artery atherosclerotic stenosis.European journal of medical research · 2023Article
- The Role of High-Resolution Magnetic Resonance Imaging in Cerebrovascular Disease: A Narrative Review.Brain sciences · 2023Review
- Circular RNA hsa_circ_0003574 as a biomarker for prediction and diagnosis of ischemic stroke caused by intracranial atherosclerotic stenosis.Frontiers in pharmacology · 2022Article
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15 authors.
Funding
Abstract
objectivesTo assess the complementary value of high-resolution multi-contrast MRI (hrMRI) in identifying symptomatic patients with intracranial atherosclerosis (ICAS) who are likely to experience recurrent ischemic cerebrovascular events.
methodsIn this retrospective cohort study, eighty patients with acute ischemic events attributed to ICAS who underwent hrMRI examination between January 2015 and January 2019 were included. Median follow-up for all patients was 30 months (range: 1 to 52 months) and recurrent ischemic cerebrovascular events were recorded. Cox regression analysis and time-dependent ROC were performed to quantify the association between the plaque characteristics and recurrent events.
resultsDuring the follow-up, 14 patients experienced recurrent ischemic cerebrovascular events. Young males and those with diabetes and poor medication persistence were more likely to experience recurrent events. ICAS in patients with recurrence had significantly higher enhancement ratio and steepness which is defined as the ratio between the plaque height and length than those without (p < 0.001 and p = 0.015, respectively). After adjustment of clinical factors, enhancement ratio (HR, 13.13 [95% CI, 3.58-48.20], p < 0.001) and plaque steepness (HR, 110.27 [95% CI, 4.75-2560.91], p = 0.003) were independent imaging biomarkers associated with recurrent events. Time-dependent ROC indicated that integrated high enhancement ratio and steepness into clinical risk factors improved discrimination power with the ROC increased from 0.79 to 0.94 (p = 0.008).
conclusionsThe enhancement ratio and plaque steepness improved the accuracy over traditional clinical risk factors in predicting recurrent ischemic cerebrovascular events for patients with ICAS. KEY POINTS: • High-resolution magnetic resonance imaging helps clinicians to evaluate high-risk Intracranial plaque. • The higher enhancement ratio and plaque steepness (= height/length) were the primary biomarkers associated with future ischemic cerebrovascular events. • High-resolution magnetic resonance imaging combined with clinical characteristics showed a higher accuracy for the prediction of recurrent events in patients with intracranial atherosclerosis.
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