Evidence map›Paper›PMID 35771153›Full record

ArticleAging2022

Sus1 maintains a normal lifespan through regulation of TREX-2 complex-mediated mRNA export.

Suji Lim, Yan Liu, Byung-Ho Rhie, Chun Kim, Hong-Yeoul Ryu, Seong Hoon Ahn

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Nuclear mRNA export.Acta biochimica et biophysica Sinica · 2024
    Review
  4. Article
  5. Article
  6. Article
  7. Nuclear mRNA Export and Aging.International journal of molecular sciences · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Suji LimDepartment of Molecular and Life Science, College of Science and Convergence Technology, Hanyang University, Ansan, Gyeonggi-do 15588, Republic of Korea.
Yan LiuDepartment of Molecular and Life Science, College of Science and Convergence Technology, Hanyang University, Ansan, Gyeonggi-do 15588, Republic of Korea.
Byung-Ho RhieDepartment of Molecular and Life Science, College of Science and Convergence Technology, Hanyang University, Ansan, Gyeonggi-do 15588, Republic of Korea.
Chun KimDepartment of Molecular and Life Science, College of Science and Convergence Technology, Hanyang University, Ansan, Gyeonggi-do 15588, Republic of Korea.
Hong-Yeoul RyuBK21 Plus KNU Creative BioResearch Group, School of Life Sciences, College of National Sciences, Kyungpook National University, Daegu 41566, Republic of Korea.
Seong Hoon AhnDepartment of Molecular and Life Science, College of Science and Convergence Technology, Hanyang University, Ansan, Gyeonggi-do 15588, Republic of Korea.
Hanyang University · KRKyungpook National University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Eukaryotic gene expression requires multiple cellular events, including transcription and RNA processing and transport. Sus1, a common subunit in both the Spt-Ada-Gcn5 acetyltransferase (SAGA) and transcription and export complex-2 (TREX-2) complexes, is a key factor in coupling transcription activation to mRNA nuclear export. Here, we report that the SAGA DUB module and TREX-2 distinctly regulate yeast replicative lifespan in a Sir2-dependent and -independent manner, respectively. The growth and lifespan impaired by

Indexed as

Saccharomyces cerevisiae ProteinsActive Transport, Cell NucleusDEAD-box RNA HelicasesExodeoxyribonucleasesGene Expression Regulation, FungalLongevityNuclear ProteinsNucleocytoplasmic Transport ProteinsPhosphoproteinsRNA-Binding ProteinsRNA, MessengerSaccharomyces cerevisiaeDBP5 protein, S cerevisiaeDEAD-box RNA HelicasesExodeoxyribonucleasesMEX67 protein, S cerevisiaeNuclear ProteinsNucleocytoplasmic Transport ProteinsPhosphoproteinsRNA-Binding ProteinsRNA, MessengerSaccharomyces cerevisiae ProteinsSus1 protein, S cerevisiaemRNA exportreplicative lifespanSAGA DUB moduleSus1TREX-2

Identifiers

PMID35771153
PMCPMC9271307
OpenAlexW4283758930

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.