Evidence map›Paper›PMID 35771078›Full record

ArticleChemistry (Weinheim an der Bergstrasse, Germany)2022

Synthesis and Biological Evaluation of Water-Soluble Esterase-Activated CO-Releasing Molecules Targeting Mitochondria.

Lars Hemmersbach, Yannick Schreiner, Xinmiao Zhang, Finn Dicke, Leon Hünemeyer, Jörg-Martin Neudörfl, Thomas Fleming, Benito Yard, Hans-Günther Schmalz

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Lars HemmersbachDepartment of Chemistry, Universität zu Köln, Greinstrasse 4, 50939, Köln, Germany.
Yannick SchreinerVth Medical Department, Medical Faculty Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany.
Xinmiao ZhangVth Medical Department, Medical Faculty Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany.
Finn DickeDepartment of Chemistry, Universität zu Köln, Greinstrasse 4, 50939, Köln, Germany.
Leon HünemeyerDepartment of Chemistry, Universität zu Köln, Greinstrasse 4, 50939, Köln, Germany.
Jörg-Martin NeudörflDepartment of Chemistry, Universität zu Köln, Greinstrasse 4, 50939, Köln, Germany.ORCID http://orcid.org/0000-0002-2918-0565
Thomas FlemingDepartment of Internal Medicine I and Clinical Chemistry, University Hospital of Heidelberg, 69120, Heidelberg, Germany.
Benito YardVth Medical Department, Medical Faculty Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany.
Hans-Günther SchmalzDepartment of Chemistry, Universität zu Köln, Greinstrasse 4, 50939, Köln, Germany.ORCID http://orcid.org/0000-0003-0489-1827
University of Cologne · DEHeidelberg University · DE

Funding

Deutsche Forschungsgemeinschaft SCHM 857-20-1Deutsche Forschungsgemeinschaft SFB1118-S01
6 · The paper itself

Abstract

Due to the beneficial effects of carbon monoxide as a cell-protective and anti-inflammatory agent, CO-releasing molecules (CORMs) offer some promising potential applications in medicine. In this context, we synthesized a set of acyloxy-cyclohexadiene-Fe(CO)

Indexed as

EsterasesOrganometallic CompoundsAnimalsAnti-Inflammatory AgentsCarbon MonoxideHumansHuman Umbilical Vein Endothelial CellsMitochondriaSwineWaterAnti-Inflammatory AgentsCarbon MonoxideEsterasesOrganometallic CompoundsWatercarbon monoxideesterasesinflammationiron carbonyl complexesprodrugs

Identifiers

PMID35771078
PMCPMC9543658
OpenAlexW4283747245

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.