Evidence map›Paper›PMID 35771007›Full record

ArticleBiochemistry2022

Primitive Phospholamban- and Sarcolipin-like Peptides Inhibit the Sarcoplasmic Reticulum Calcium Pump SERCA.

Jessi J Bak, Rodrigo Aguayo-Ortiz, Nishadh Rathod, Joseph O Primeau, Muhammad Bashir Khan, Seth L Robia, M Joanne Lemieux, L Michel Espinoza-Fonseca, Howard S Young

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Review
  6. Replacement of Lys27 by asparagine in the SERCA regulator myoregulin: A CaBiochimica et biophysica acta. Molecular cell research · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Jessi J BakDepartment of Biochemistry, University of Alberta, Edmonton, Alberta T6G 2H7, Canada.
Rodrigo Aguayo-OrtizCenter for Arrhythmia Research, Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan 48109, United States.
Nishadh RathodDepartment of Biochemistry, University of Alberta, Edmonton, Alberta T6G 2H7, Canada.
Joseph O PrimeauDepartment of Biochemistry, University of Alberta, Edmonton, Alberta T6G 2H7, Canada.
Muhammad Bashir KhanDepartment of Biochemistry, University of Alberta, Edmonton, Alberta T6G 2H7, Canada.
Seth L RobiaDepartment of Cell and Molecular Physiology, Loyola University Chicago, Maywood, Illinois 60153, United States.ORCID 0000-0002-1193-9510
M Joanne LemieuxDepartment of Biochemistry, University of Alberta, Edmonton, Alberta T6G 2H7, Canada.ORCID 0000-0003-4745-9153
L Michel Espinoza-FonsecaCenter for Arrhythmia Research, Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan 48109, United States.
Howard S YoungDepartment of Biochemistry, University of Alberta, Edmonton, Alberta T6G 2H7, Canada.ORCID 0000-0002-5990-8422
University of Alberta · CAUniversity of Michigan · USLoyola University Chicago · US

Funding

Structural Determinants of Calcium Pump RegulationR01HL092321 · NHLBI · LOYOLA UNIVERSITY CHICAGO · PI Seth L Robia · 2008 to 2026
$8.9M
Molecular mechanisms and regulation of the calcium pump in the heartR01GM120142 · NIGMS · UNIVERSITY OF MINNESOTA · PI ESPINOZA-FONSECA, LENNANE MICHEL · 2016 to 2020
$1.7M
NHLBI NIH HHS R01 HL092321NIGMS NIH HHS R01 GM120142
6 · The paper itself

Abstract

Intracellular calcium signaling is essential for all kingdoms of life. An important part of this process is the sarco-endoplasmic reticulum Ca

Indexed as

CalciumSarcoplasmic ReticulumAnimalsCalcium-Binding ProteinsCalcium SignalingHumansMammalsMolecular Dynamics SimulationMuscle ProteinsPeptidesPhospholambanProteolipidsSarcoplasmic Reticulum Calcium-Transporting ATPasesCalciumCalcium-Binding ProteinsMuscle ProteinsPeptidesPhospholambanProteolipidssarcolipinSarcoplasmic Reticulum Calcium-Transporting ATPases

Identifiers

PMID35771007
PMCPMC10588654
OpenAlexW4283723566

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.