ArticleThe Journal of comparative neurology2022
Organization of neural systems expressing melanocortin-3 receptors in the mouse brain: Evidence for sexual dimorphism.
Article in The Journal of comparative neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 20 citations in OpenAlex.
- The causes of cachexia: key signals and the brain.Nature reviews. Endocrinology · 2026Review
- Sex-differential associations of MC3R p.F45S with human metabolic profile.Journal of neuroendocrinology · 2026Article
- Sexual dimorphism in the development and function of the melanocortin system.Reviews in endocrine & metabolic disorders · 2026Review
- Perinatal consumption of a thermally processed diet alters feeding behavior and has sex-dependent effects upon metabolism in later life in mice.Food chemistry. Molecular sciences · 2026Article
- Dual activation of MC3R and MC4R drives weight loss and reduces food intake in male primates with obesity.Nature communications · 2026Article
- The melanocortin receptors as targets for general obesity: contextualizing clinical failures and analyzing future perspectives.Frontiers in endocrinology · 2026Review
- Ghrelin Increases Glutamate Release at the Perforant Path-Dentate Gyrus Granule Cell Synapses by Cross-Activating Dopamine DJournal of cellular physiology · 2025Article
- Suppression of binge alcohol drinking by an inhibitory neuronal ensemble in the mouse medial orbitofrontal cortex.Nature neuroscience · 2025Article
- The ventral premammillary nucleus at the interface of environmental cues and social behaviors.Frontiers in neuroscience · 2025Review
- Medial hypothalamic MC3R signalling regulates energy rheostasis in adult mice.The Journal of physiology · 2025Article
- Fasting-induced activity changes in MC3R neurons of the paraventricular nucleus of the thalamus.Life science alliance · 2024Article
- Subthreshold activation of the melanocortin system causes generalized sensitization to anorectic agents in mice.The Journal of clinical investigation · 2024Article
- An orbitocortical-thalamic circuit suppresses binge alcohol-drinking.bioRxiv : the preprint server for biology · 2024Article
- Neuroanatomical dissection of the MC3R circuitry regulating energy rheostasis.bioRxiv : the preprint server for biology · 2024Article
- Melanocortin agonism in a social context selectively activates nucleus accumbens in an oxytocin-dependent manner.Neuropharmacology · 2024Article
- Melanocortin-3 receptor expression in AgRP neurons is required for normal activation of the neurons in response to energy deficiency.Cell reports · 2023Article
- Paraventricular ThalamicThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Targeting the central melanocortin system for the treatment of metabolic disorders.Nature reviews. Endocrinology · 2023Review
- Structural insights into ligand recognition and subtype selectivity of the human melanocortin-3 and melanocortin-5 receptors.Cell discovery · 2023Article
- Melanocortin receptor 3 and 4 mRNA expression in the adult female Syrian hamster brain.Frontiers in molecular neuroscience · 2023Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
The central melanocortin system is fundamentally important for controlling food intake and energy homeostasis. Melanocortin-3 receptor (MC3R) is one of two major receptors of the melanocortin system found in the brain. In contrast to the well-characterized melanocortin-4 receptor (MC4R), little is known regarding the organization of MC3R-expressing neural circuits. To increase our understanding of the intrinsic organization of MC3R neural circuits, identify specific differences between males and females, and gain a neural systems level perspective of this circuitry, we conducted a brain-wide mapping of neurons labeled for MC3R and characterized the distribution of their projections. Analysis revealed MC3R neuronal and terminal labeling in multiple brain regions that control a diverse range of physiological functions and behavioral processes. Notably, dense labeling was observed in the hypothalamus, as well as areas that share considerable connections with the hypothalamus, including the cortex, amygdala, thalamus, and brainstem. Additionally, MC3R neuronal labeling was sexually dimorphic in several areas, including the anteroventral periventricular area, arcuate nucleus, principal nucleus of the bed nucleus of the stria terminalis, and ventral premammillary region. Altogether, anatomical evidence reported here suggests that MC3R has the potential to influence several different classes of motivated behavior that are essential for survival, including ingestive, reproductive, defensive, and arousal behaviors, and is likely to modulate these behaviors differently in males and females.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.