ArticleAnnals of Saudi medicine
Prognosis of gastric adenocarcinoma associated with girdin, Akt, and cortactin.
Article in Annals of Saudi medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed, 13 citations in OpenAlex.
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Authors and funding
3 authors at 1 institution in 1 country.
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Abstract
backgroundThe actin-binding protein girdin regulates tumor cell migration and invasion by maintaining actin structure. PI3K/Akt signaling is an important actin-remodeling pathway. The protein cortactin acts directly on microfilaments and promotes tumor invasion and metastasis by rearranging the cytoskeleton. However, there are few reports on the co-expression of girdin, Akt, and cortactin in gastric adenocarcinoma (GAC).
objectivesEvaluate girdin, Akt, and cortactin expression in GAC tissues and assess their relationship to the prognosis of GAC patients.
designSurvival analysis
settingMedical college in China PATIENTS AND
methodsWe compared survival in 110 paraffin-preserved GAC with corresponding normal gastric mucosa tissues in relationship to girdin, Akt, and cortactin expression levels.
main outcome measureExpression levels of the proteins. SAMPLE SIZE: 110
resultsThe expression of girdin, Akt, and cortactin were all upregulated in GAC tissues compared with corresponding normal tissues (66.4% vs 36.3%, 57.3% vs 28.2% and 69.1% vs 22.7%, respectively;
conclusionsGirdin and cortactin may promote GAC invasion and metastasis via the PI3-K/Akt signaling pathway. Girdin, Akt, and cortactin co-expression might serve as a novel molecular target for GAC therapy and improve the prognosis of patients with this disease. LIMITATIONS: A small sample size and lack of related research on molecular mechanisms. CONFLICT OF INTEREST: None.
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