Evidence map›Paper›PMID 35770931›Full record

ArticleMedical decision making : an international journal of the Society for Medical Decision Making2023

An Introductory Tutorial on Cohort State-Transition Models in R Using a Cost-Effectiveness Analysis Example.

Fernando Alarid-Escudero, Eline Krijkamp, Eva A Enns, Alan Yang, M G Myriam Hunink, Petros Pechlivanoglou, Hawre Jalal

Abstract read
In one paragraph

Article in Medical decision making : an international journal of the Society for Medical Decision Making, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. A Tutorial on Discrete Event Simulation Models Using a Cost-Effectiveness Analysis Example in R.Medical decision making : an international journal of the Society for Medical Decision Making · 2026
    Article
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  12. Review
  13. Meta-Modeling as a Variance-Reduction Technique for Stochastic Model-Based Cost-Effectiveness Analyses.Medical decision making : an international journal of the Society for Medical Decision Making · 2025
    Article
  14. Modeling Disability-Adjusted Life-Years for Policy and Decision Analysis.Medical decision making : an international journal of the Society for Medical Decision Making · 2025
    Article
  15. Cost and Cost-Effectiveness of Treating Human Epidermal Growth Factor Receptor 2-Low Metastatic Breast Cancer.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2025
    Article
  16. Article
  17. Article
  18. Article
  19. A Tutorial on Time-Dependent Cohort State-Transition Models in R Using a Cost-Effectiveness Analysis Example.Medical decision making : an international journal of the Society for Medical Decision Making · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Fernando Alarid-EscuderoDivision of Public Administration, Center for Research and Teaching in Economics (CIDE), Aguascalientes, Aguascalientes, Mexico.ORCID 0000-0001-5076-1172
Eline KrijkampDepartment of Epidemiology and Department of Radiology, Erasmus University Medical Center, Rotterdam, The Netherlands.ORCID 0000-0003-3970-2205
Eva A EnnsDivision of Health Policy and Management, University of Minnesota School of Public Health, Minneapolis, MN, USA.
Alan YangThe Hospital for Sick Children, Toronto, Ontario, Canada.ORCID 0000-0002-0344-6812
M G Myriam HuninkDepartment of Epidemiology and Department of Radiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Petros PechlivanoglouThe Hospital for Sick Children, Toronto and University of Toronto, Toronto, Ontario, Canada.
Hawre JalalSchool of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.ORCID 0000-0002-8224-6834

Funding

Comparative Modeling of Effective Policies for Colorectal Cancer ControlU01CA253913 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI RUTTER, CAROLYN M, ZAUBER, ANN GRAHAM · 2020 to 2025
$6.5M
Comparative Modeling of Colorectal Cancer: Informing Health Policies and Prioritizing Future ResearchU01CA199335 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI KUNTZ, KAREN M, LANSDORP-VOGELAAR, IRIS · 2015 to 2019
$5.5M
Population Modeling of Bladder Cancer Detection and ControlU01CA265750 · NCI · BROWN UNIVERSITY · PI JALAL, HAWRE, TRIKALINOS, THOMAS · 2021 to 2025
$3.4M
Mathematical modeling and analysis of HIV care trajectories and retention in care challengesK25AI118476 · NIAID · UNIVERSITY OF MINNESOTA · PI ENNS, EVA A · 2015 to 2019
$649k
Understanding the Impact of Opioid Policies on the Opioid Epidemic Using Graphical Causal Models and Causal DiscoveryK01DA048985 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JALAL, HAWRE · 2020 to 2021
$360k
NCI NIH HHS U01 CA199335NCI NIH HHS U01 CA253913NCI NIH HHS U01 CA265750NIAID NIH HHS K25 AI118476NIDA NIH HHS K01 DA048985
6 · The paper itself

Abstract

Decision models can combine information from different sources to simulate the long-term consequences of alternative strategies in the presence of uncertainty. A cohort state-transition model (cSTM) is a decision model commonly used in medical decision making to simulate the transitions of a hypothetical cohort among various health states over time. This tutorial focuses on time-independent cSTM, in which transition probabilities among health states remain constant over time. We implement time-independent cSTM in R, an open-source mathematical and statistical programming language. We illustrate time-independent cSTMs using a previously published decision model, calculate costs and effectiveness outcomes, and conduct a cost-effectiveness analysis of multiple strategies, including a probabilistic sensitivity analysis. We provide open-source code in R to facilitate wider adoption. In a second, more advanced tutorial, we illustrate time-dependent cSTMs.

Indexed as

Cost-Effectiveness AnalysisProgramming LanguagesCost-Benefit AnalysisHumansMarkov ChainsProbabilityQuality-Adjusted Life YearsSoftwarecohort state-transition modelscost-effectiveness analysisMarkov modelsR softwaretutorial

Identifiers

PMID35770931
PMCPMC9742144

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.