Evidence map›Paper›PMID 35770874›Full record

ReviewJournal of experimental botany2022

Translating across kingdoms: target of rapamycin promotes protein synthesis through conserved and divergent pathways in plants.

M Regina Scarpin, Carl H Simmons, Jacob O Brunkard

Open access · greenAbstract readReview
In one paragraph

Review in Journal of experimental botany, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
4.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Genetic suppressor ofFrontiers in plant science · 2025
    Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Growing of the TOR world.Journal of experimental botany · 2022
    Article
  15. Conserved Functions of LARP1 Proteins in Eukaryotes.Wiley interdisciplinary reviews. RNA
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

M Regina ScarpinLaboratory of Genetics, University of Wisconsin, Madison, WI, USA.ORCID 0000-0002-6454-7721
Carl H SimmonsLaboratory of Genetics, University of Wisconsin, Madison, WI, USA.ORCID 0000-0003-1604-3040
Jacob O BrunkardLaboratory of Genetics, University of Wisconsin, Madison, WI, USA.ORCID 0000-0001-6407-9393
Agricultural Research Service · USUniversity of Wisconsin–Madison · US

Funding

An aminoacyl tRNA synthetase is a nitrogen sensor that activates TOR in plantsDP5OD023072 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI BRUNKARD, JACOB O · 2016 to 2020
$1.6M
NIH HHS DP5 OD023072
6 · The paper itself

Abstract

mRNA translation is the growth rate-limiting step in genome expression. Target of rapamycin (TOR) evolved a central regulatory role in eukaryotes as a signaling hub that monitors nutrient availability to maintain homeostasis and promote growth, largely by increasing the rate of translation initiation and protein synthesis. The dynamic pathways engaged by TOR to regulate translation remain debated even in well-studied yeast and mammalian models, however, despite decades of intense investigation. Recent studies have firmly established that TOR also regulates mRNA translation in plants through conserved mechanisms, such as the TOR-LARP1-5'TOP signaling axis, and through pathways specific to plants. Here, we review recent advances in our understanding of the regulation of mRNA translation in plants by TOR.

Indexed as

PlantsSirolimusRNA, MessengerSignal TransductionRNA, MessengerSirolimus5ʹTOP motifsArabidopsis thalianaevolutionkinase signalingLARP1protein synthesisribosomestarget of rapamycinTORtranslation

Identifiers

PMID35770874
PMCPMC9664230
OpenAlexW4283744002

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.