ArticleJournal of biomedical materials research. Part A2022
Can strontium replace calcium in bioactive materials for dental applications?
Article in Journal of biomedical materials research. Part A, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 25 citations in OpenAlex.
- Clinical outcomes of nonsurgical root canal treatment using C-root SP combined with different obturation techniques in older patients: a randomized controlled clinical trial.BMC oral health · 2025Trial
- Cytotoxicity and Bioactivity of Five Hydraulic Silicate Cements in Human Dental Pulp Cells at Different Setting Stages.International dental journal · 2026Article
- Dentine Regeneration With Calcium Strontium Silicate: In Vitro Odontogenic Differentiation, Antimicrobial Activity, Immunomodulation and In Vivo Pulpotomy in Rat Molars.International endodontic journal · 2026Article
- Microhardness and Chemical Composition of Glass Ionomer and Glass Hybrid Cements Modified with Experimental Bioactive Glasses.Acta stomatologica Croatica · 2026Article
- Article
- Characterization, in-vitro biological and antimicrobial testing of replacing Sr/Ca in wollastonite (CaScientific reports · 2026Article
- Assessing Sealing Ability of C-Root SP Strontium Silicate Sealer With Different Obturation Techniques: An in vitro Study.International dental journal · 2026Article
- Evaluation of fluoride and calcium ion release and fluoride recharge capacity of glass-ionomer materials modified with experimental bioactive glass.Scientific reports · 2025Article
- The Effect of Irrigation Solutions on the Setting Time, Solubility, and pH of Three Types of Premixed Bioceramic-Based Root Canal Sealers.International journal of dentistry · 2025Article
- Applications of Bioactive Strontium Compounds in Dentistry.Journal of functional biomaterials · 2024Review
- Advanced Dentistry Biomaterials Containing Graphene Oxide.Polymers · 2024Article
- Impact of ZrOMaterials (Basel, Switzerland) · 2024Article
- Sustainable Release Selenium Laden with SiOInternational journal of nanomedicine · 2024Article
- Synthesis of a Calcium Silicate Cement Containing a Calcinated Strontium Silicate Phase.International journal of dentistry · 2024Article
- A Systematic Review on the Effect of Strontium-Doped Nanohydroxyapatite in Remineralizing Early Caries Lesion.Cureus · 2023Review
- Can strontium replace calcium in bioactive materials for dental applications?Journal of biomedical materials research. Part A · 2022Article
- Physicochemical Properties and Inductive Effect of Calcium Strontium Silicate on the Differentiation of Human Dental Pulp Stem Cells for Vital Pulp Therapies: An In Vitro Study.Materials (Basel, Switzerland) · 2022Article
Corrections and comments
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Authors and funding
11 authors at 6 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The substitution of calcium with strontium in bioactive materials has been promising but there has been some concern over the material instability and possible toxicity. The aim of this research was the synthesis and characterization of calcium and strontium substituted bioactive materials and assessment of interactions with local tissues and peripheral elemental migration in an animal model. A bioactive glass, hydroxyapatite and hydraulic calcium silicate with 50% or 100% calcium substitution with strontium were developed and the set materials were characterized immediately after setting and after 30 and 180-days in solution. Following subcutaneous implantation, the local (tissue histology, elemental migration) and systemic effects (elemental deposition after organ digestion) were assessed. The strontium-replaced silicate cements resulted in the synthesis of partially substituted phases and strontium leaching at all-time points. The strontium silicate implanted in the animal model could not be retrieved in over half of the specimens showing the high rate of material digestion. Tissue histology showed that all materials caused inflammation after 30 days of implantation however this subsided and angiogenesis occurred after 180 days. Strontium was not detected in the local tissues or the peripheral organs while all calcium containing materials caused calcium deposition in the kidneys. The tricalcium silicate caused elemental migration of calcium and silicon in the local tissues shown by the elemental mapping but no deposition of calcium was identified in the peripheral organs verified by the assessment of the digested tissues. Strontium can substitute calcium in bioactive materials without adverse local or systemic effects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.