ArticleEnvironmental toxicology and chemistry2022
BeeGUTS-A Toxicokinetic-Toxicodynamic Model for the Interpretation and Integration of Acute and Chronic Honey Bee Tests.
Article in Environmental toxicology and chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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Who cites it
4 citing papers in PubMed.
- Simulation of the Impact of Pesticides on Pollinators Under Different Conditions Using Correlation Weighting of Quasi-SMILES Components Together with the Index of Ideality of Correlation (IIC).Journal of xenobiotics · 2026Article
- Combined Modeling of Multiple Exposure Routes for Terrestrial Arthropods Using the Toxicokinetic-Toxicodynamic BufferGUTS Model.Environmental science & technology · 2025Article
- From water to land-Usage of Generalized Unified Threshold models of Survival (GUTS) in an above-ground terrestrial context exemplified by honeybee survival data.Environmental toxicology and chemistry · 2025Article
- Correspondence on "Mortality Pattern ofEnvironmental science & technology · 2024Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Understanding the survival of honey bees after pesticide exposure is key for environmental risk assessment. Currently, effects on adult honey bees are assessed by Organisation for Economic Co-operation and Development standardized guidelines, such as the acute and chronic oral exposure and acute contact exposure tests. The three different tests are interpreted individually, without consideration that the same compound is investigated in the same species, which should allow for an integrative assessment. In the present study we developed, calibrated, and validated a toxicokinetic-toxicodynamic model with 17 existing data sets on acute and chronic effects for honey bees. The model is based on the generalized unified threshold model for survival (GUTS), which is able to integrate the different exposure regimes, taking into account the physiology of the honey bee: the BeeGUTS model. The model is able to accurately describe the effects over time for all three exposure routes combined within one consistent framework. The model can also be used as a validity check for toxicity values used in honey bee risk assessment and to conduct effect assessments for real-life exposure scenarios. This new integrative approach, moving from single-point estimates of toxicity and exposure to a holistic link between exposure and effect, will allow for a higher confidence of honey bee toxicity assessment in the future. Environ Toxicol Chem 2022;41:2193-2201. © 2022 The Authors. Environmental Toxicology and Chemistry published by Wiley Periodicals LLC on behalf of SETAC.
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