ReviewScandinavian journal of medicine & science in sports2022
Physical activity and health: Findings from Finnish monozygotic twin pairs discordant for physical activity.
Review in Scandinavian journal of medicine & science in sports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Physical Activity and Metabolic Alterations in Children and Adolescents Across Different Weight Groups: A Systematic Review.European journal of sport science · 2026Pooled it
- Associations of smoking status and leisure-time physical activity with waist circumference change-10-year follow-up among twin adults.International journal of obesity (2005) · 2025Article
- Biomarkers of aging: from molecules and surrogates to physiology and function.Physiological reviews · 2025Review
- Metabolomics efficiently discriminates monozygotic twins in peripheral blood.International journal of legal medicine · 2024Article
- Genetic Liability to Cardiovascular Disease, Physical Activity, and Mortality: Findings from the Finnish Twin Cohort.Medicine and science in sports and exercise · 2024Article
- Article
- The molecular athlete: exercise physiology from mechanisms to medals.Physiological reviews · 2023Review
- Physical activity and health: Findings from Finnish monozygotic twin pairs discordant for physical activity.Scandinavian journal of medicine & science in sports · 2022Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Genetic and early environmental differences including early health habits associate with future health. To provide insight on the causal nature of these associations, monozygotic (MZ) twin pairs discordant for health habits provide an interesting natural experiment. Twin pairs discordant for leisure-time physical activity (LTPA) in early adult life is thus a powerful study design to investigate the associations between long-term LTPA and indicators of health and wellbeing. We have identified 17 LTPA discordant twin pairs from two Finnish twin cohorts and summarize key findings of these studies in this paper. The carefully characterized rare long-term LTPA discordant MZ twin pairs have participated in multi-dimensional clinical examinations. Key findings highlight that compared with less active twins in such MZ twin pairs, the twins with higher long-term LTPA have higher physical fitness, reduced body fat, reduced visceral fat, reduced liver fat, increased lumen diameters of conduit arteries to the lower limbs, increased bone mineral density in loaded bone areas, and an increased number of large high-density lipoprotein particles. The findings increase our understanding on the possible site-specific and system-level effects of long-term LTPA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.