Evidence map›Paper›PMID 35770188›Full record

ReviewFrontiers in physiology2022

The Functions and Mechanisms of Basic Fibroblast Growth Factor in Tendon Repair.

Jingwei Lu, Li Jiang, Yixuan Chen, Kexin Lyu, Bin Zhu, Yujie Li, Xueli Liu, Xinyue Liu, Longhai Long, Xiaoqiang Wang and 3 more

Registry-linked trialOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07659600 (Performance of Autologous Platelet-rich Plasma Injection for Tendon Regeneration in Partial Supraspinatus Tears), which is not on this map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
7.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07659600 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Performance of Autologous Platelet-rich Plasma Injection for Tendon Regeneration in Partial Supraspinatus Tears

TypeinterventionalSponsorUniversidade Nova de LisboaRan2026 to 2029Enrolled100ConditionsPartial Supraspinatus Tear, Rotator Cuff Tears (RCTs), Rotator Cuff InjuryArmsPlatelet-Rich Plasma (PRP) Injections
3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 48 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Trial
  4. Article
  5. Review
  6. Article
  7. The Secretome From Mechanically Loaded Myoblasts Enhances Tenocyte-Mediated Wound Healing in a 3D In Vitro Tendon Model.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  8. Review
  9. Review
  10. Review
  11. Review
  12. Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Jingwei LuSchool of Physical Education, Southwest Medical University, Luzhou, China.
Li JiangSchool of Physical Education, Southwest Medical University, Luzhou, China.
Yixuan ChenSchool of Physical Education, Southwest Medical University, Luzhou, China.
Kexin LyuSchool of Physical Education, Southwest Medical University, Luzhou, China.
Bin ZhuSchool of Physical Education, Southwest Medical University, Luzhou, China.
Yujie LiSchool of Physical Education, Southwest Medical University, Luzhou, China.
Xueli LiuSchool of Physical Education, Southwest Medical University, Luzhou, China.
Xinyue LiuSchool of Physical Education, Southwest Medical University, Luzhou, China.
Longhai LongThe Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, China.
Xiaoqiang WangThe Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, China.
Houping XuThe Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, China.
Dingxuan WangSchool of Physical Education, Southwest Medical University, Luzhou, China.
Sen LiThe Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, China.
Southwest Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tendon injury is a disorder of the musculoskeletal system caused by overuse or trauma, which is characterized by pain and limitations in joint function. Since tendon healing is slowly and various treatments are generally ineffective, it remains a clinically challenging problem. Recent evidences suggest that basic fibroblast growth factor (bFGF) not only plays an important role in tendon healing, but also shows a positive effect in laboratory experimentations. The purpose of this review is to summarize the effects of bFGF in the tendon healing. Firstly, during the inflammatory phase, bFGF stimulates the proliferation and differentiation of vascular endothelial cells to foster neovascularization. Furthermore, bFGF enhances the production of pro-inflammatory factors during the early phase of tendon healing, thereby accelerating the inflammatory response. Secondly, the cell proliferation phase is accompanied by the synthesis of a large number of extracellular matrix components. bFGF speeds up tendon healing by stimulating fibroblasts to secrete type III collagen. Lastly, the remodeling phase is characterized by the transition from type III collagen to type I collagen, which can be promoted by bFGF. However, excessive injection of bFGF can cause tendon adhesions as well as scar tissue formation. In future studies, we need to explore further applications of bFGF in the tendon healing process.

Indexed as

basic fiboblast growth factormechanismtendon healingtendon injurytendon repair

Identifiers

PMID35770188
PMCPMC9234302
OpenAlexW4282589016

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.