ArticleBrain communications2022
Prefrontal-amygdala emotion regulation and depression in multiple sclerosis.
Article in Brain communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- Brain connectivity changes underlying depression and fatigue in relapsing-remitting multiple sclerosis: A systematic review.PloS one · 2024Pooled it
- Repeated prefrontal tDCS for improving mental health and cognitive deficits in multiple sclerosis: a randomized, double-blind, parallel-group study.Journal of translational medicine · 2024Trial
- Shedding Light on Interaction Between Neurological Symptoms and Psychiatric Episodes in Multiple Sclerosis: Novel Hypothesis and Therapeutic Avenues.Molecular neurobiology · 2026Review
- Investigating Depression and MRI Associations in Middle Eastern Relapsing-Remitting Multiple Sclerosis.Journal of biomedical physics & engineering · 2026Article
- Neurobehavioral mechanisms of fear and anxiety in multiple sclerosis.Communications medicine · 2025Article
- Unraveling Hierarchical Brain Dysfunction in Major Depressive Disorder: A Multimodal Imaging and Transcriptomic Approach.Human brain mapping · 2025Article
- Amygdala volume changes as a potential marker of multiple sclerosis progression: links to EDSS scores and PIRA.Frontiers in immunology · 2025Article
- Addiction Memory, Family Functioning, and Depression in Illicit Drug Users: Self-Esteem as a Mediator.Behavioral sciences (Basel, Switzerland) · 2024Article
- Review
- Predictive Model of Anxiety and Depression Perception in Multiple Sclerosis Patients: Possible Implications for Clinical Treatment.Bioengineering (Basel, Switzerland) · 2024Article
- Understanding the spectrum of non-motor symptoms in multiple sclerosis: insights from animal models.Neural regeneration research · 2024Review
- A review on multiple sclerosis prognostic findings from imaging, inflammation, and mental health studies.Frontiers in human neuroscience · 2023Review
- Factors associated with depressive mood at the onset of multiple sclerosis - an analysis of 781 patients of the German NationMS cohort.Therapeutic advances in neurological disorders · 2023Article
- Exploring causal links between brain functional networks and neurodegenerative disease risk using Mendelian randomization.Journal of Alzheimer's disease reportsArticle
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Depression is among the most common comorbidities in multiple sclerosis and has severe psychosocial consequences. Alterations in neural emotion regulation in amygdala and prefrontal cortex have been recognized as key mechanism of depression but never been investigated in multiple sclerosis depression. In this cross-sectional observational study, we employed a functional MRI task investigating neural emotion regulation by contrasting regulated versus unregulated negative stimulus perception in 16 persons with multiple sclerosis and depression (47.9 ± 11.8 years; 14 female) and 26 persons with multiple sclerosis but without depression (47.3 ± 11.7 years; 14 female). We tested the impact of depression and its interaction with lesions in amygdala-prefrontal fibre tracts on brain activity reflecting emotion regulation. A potential impact of sex, age, information processing speed, disease duration, overall lesion load, grey matter fraction, and treatment was taken into account in these analyses. Patients with depression were less able (i) to downregulate negative emotions than those without (
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