Evidence map›Paper›PMID 35770017›Full record

ReviewFrontiers in medicine2022

Blood Flow Restriction Training for the Intervention of Sarcopenia: Current Stage and Future Perspective.

Xu-Zhi Zhang, Wen-Qing Xie, Lin Chen, Guo-Dong Xu, Li Wu, Yu-Sheng Li, Yu-Xiang Wu

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 2 pooled it
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 27 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. [Effects of Blood Flow Restriction Training on Muscle Strength and Physical Function in Older Adults With Sarcopenia].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2026
    Trial
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Prevention of Sarcopenia.Advances in experimental medicine and biology · 2025
    Review
  14. Review
  15. Review
  16. Article
  17. Review
  18. Review
  19. Article
  20. The Association Between Sarcopenia and Diabetes: From Pathophysiology Mechanism to Therapeutic Strategy.Diabetes, metabolic syndrome and obesity : targets and therapy · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Xu-Zhi ZhangDepartment of Orthopedics, Xiangya Hospital, Central South University, Changsha, China.
Wen-Qing XieDepartment of Orthopedics, Xiangya Hospital, Central South University, Changsha, China.
Lin ChenDepartment of Health and Kinesiology, School of Physical Education, Jianghan University, Wuhan, China.
Guo-Dong XuDepartment of Health and Kinesiology, School of Physical Education, Jianghan University, Wuhan, China.
Li WuDepartment of Health and Kinesiology, School of Physical Education, Jianghan University, Wuhan, China.
Yu-Sheng LiDepartment of Orthopedics, Xiangya Hospital, Central South University, Changsha, China.
Yu-Xiang WuDepartment of Health and Kinesiology, School of Physical Education, Jianghan University, Wuhan, China.
Jianghan University · CNXiangya Hospital Central South University · CNCentral South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sarcopenia is a geriatric syndrome that is characterized by a progressive and generalized skeletal muscle disorder and can be associated with many comorbidities, including obesity, diabetes, and fracture. Its definitions, given by the AWGS and EWGSOP, are widely used. Sarcopenia is measured by muscle strength, muscle quantity or mass and physical performance. Currently, the importance and urgency of sarcopenia have grown. The application of blood flow restriction (BFR) training has received increased attention in managing sarcopenia. BFR is accomplished using a pneumatic cuff on the proximal aspect of the exercising limb. Two main methods of exercise, aerobic exercise and resistance exercise, have been applied with BFR in treating sarcopenia. Both methods can increase muscle mass and muscle strength to a certain extent. Intricate mechanisms are involved during BFRT. Currently, the presented mechanisms mainly include responses in the blood vessels and related hormones, such as growth factors, tissue hypoxia-related factors and recruitment of muscle fiber as well as muscle satellite cells. These mechanisms contribute to the positive balance of skeletal muscle synthesis, which in turn mitigates sarcopenia. As a more suited and more effective way of treating sarcopenia and its comorbidities, BFRT can serve as an alternative to traditional exercise for people who have marked physical limitations or even show superior outcomes under low loads. However, the possibility of causing stress or muscle damage must be considered. Cuff size, pressure, training load and other variables can affect the outcome of sarcopenia, which must also be considered. Thoroughly studying these factors can help to better determine an ideal BFRT scheme and better manage sarcopenia and its associated comorbidities. As a well-tolerated and novel form of exercise, BFRT offers more potential in treating sarcopenia and involves deeper insights into the function and regulation of skeletal muscle.

Indexed as

aerobic trainingagingblood flow restriction trainingresistance trainingsarcopenia

Identifiers

PMID35770017
PMCPMC9234289
OpenAlexW4282546707

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.