Evidence map›Paper›PMID 35769884›Full record

ArticleiScience2022

Dendritic peptide-conjugated polymeric nanovectors for non-toxic delivery of plasmid DNA and enhanced non-viral transfection of immune cells.

Sijia Yi, Sun-Young Kim, Michael P Vincent, Simseok A Yuk, Sharan Bobbala, Fanfan Du, Evan Alexander Scott

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Sijia YiDepartment of Biomedical Engineering, Northwestern University, Evanston, IL 60208, USA.
Sun-Young KimDepartment of Biomedical Engineering, Northwestern University, Evanston, IL 60208, USA.
Michael P VincentDepartment of Biomedical Engineering, Northwestern University, Evanston, IL 60208, USA.
Simseok A YukDepartment of Biomedical Engineering, Northwestern University, Evanston, IL 60208, USA.
Sharan BobbalaDepartment of Pharmaceutical Sciences, School of Pharmacy, West Virginia University, Morgantown, WV 26505, USA.
Fanfan DuDepartment of Biomedical Engineering, Northwestern University, Evanston, IL 60208, USA.
Evan Alexander ScottDepartment of Biomedical Engineering, Northwestern University, Evanston, IL 60208, USA.
Northwestern University · USWest Virginia University · US

Funding

Design and characterization of biomimetic nanobiomaterials to elicit CD1-restricted T cell responses during sub-unit vaccinationR01AI145345 · NIAID · NORTHWESTERN UNIVERSITY · PI SCOTT, EVAN ALEXANDER, WANG, CHYUNG-RU · 2019 to 2022
$2.9M
Development of combination immunotherapies for atherosclerotic inflammationDP2HL132390 · NHLBI · NORTHWESTERN UNIVERSITY · PI SCOTT, EVAN ALEXANDER · 2015 to 2015
$2.3M
Visual Sciences T32T32EY025202 · NEI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Gregory William Schwartz · 2015 to 2026
$1.4M
NEI NIH HHS T32 EY025202NHLBI NIH HHS DP2 HL132390NIAID NIH HHS R01 AI145345
6 · The paper itself

Abstract

Plasmid DNA (pDNA) transfection is advantageous for gene therapies requiring larger genetic elements, including "all-in-one" CRISPR/Cas9 plasmids, but is limited by toxicity as well as poor intracellular release and transfection efficiency in immune cell populations. Here, we developed a synthetic non-viral gene delivery platform composed of poly(ethylene glycol)-

Indexed as

Biological sciencesBiotechnologyDrug delivery systemHealth sciencesImmunology

Identifiers

PMID35769884
PMCPMC9234717
OpenAlexW4283756763

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.