Evidence map›Paper›PMID 35769482›Full record

ArticleFrontiers in immunology2022

Regulatory Architecture of the RCA Gene Cluster Captures an Intragenic TAD Boundary, CTCF-Mediated Chromatin Looping and a Long-Range Intergenic Enhancer.

Jessica Cheng, Joshua S Clayton, Rafael D Acemel, Ye Zheng, Rhonda L Taylor, Sündüz Keleş, Martin Franke, Susan A Boackle, John B Harley, Elizabeth Quail and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
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  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 9 institutions in 3 countries.

Jessica ChengSchool of Biomedical Sciences, The University of Western Australia, Crawley, WA, Australia.
Joshua S ClaytonHarry Perkins Institute of Medical Research, QEII Medical Centre, Nedlands, WA, Australia.
Rafael D AcemelCentro Andaluz de Biología del Desarrollo, Consejo Superior de Investigaciones Científicas/Universidad Pablo de Olavide, Sevilla, Spain.
Ye ZhengVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States.
Rhonda L TaylorHarry Perkins Institute of Medical Research, QEII Medical Centre, Nedlands, WA, Australia.
Sündüz KeleşDepartment of Statistics, University of Wisconsin-Madison, Madison, WI, United States.
Martin FrankeCentro Andaluz de Biología del Desarrollo, Consejo Superior de Investigaciones Científicas/Universidad Pablo de Olavide, Sevilla, Spain.
Susan A BoackleDepartment of Medicine, Division of Rheumatology, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.
John B HarleyCenter for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States.
Elizabeth QuailSchool of Biomedical Sciences, The University of Western Australia, Crawley, WA, Australia.
José Luis Gómez-SkarmetaCentro Andaluz de Biología del Desarrollo, Consejo Superior de Investigaciones Científicas/Universidad Pablo de Olavide, Sevilla, Spain.
Daniela UlgiatiSchool of Biomedical Sciences, The University of Western Australia, Crawley, WA, Australia.
University of Western Australia · AUCentro Andaluz de Biología del Desarrollo · ESConsejo Superior de Investigaciones Científicas · ESFred Hutch Cancer Center · USHarry Perkins Institute of Medical Research · AUQueen Elizabeth II Medical Centre · AUUnited States Department of Veterans Affairs · USUniversity of Colorado Anschutz Medical Campus · USUniversity of Wisconsin–Madison · US

Funding

HLA GENE COMPLEMENTATION IN PRIMARY SJOGREN'S AND LUPUSR01AI024717 · NIAID · OKLAHOMA MEDICAL RESEARCH FOUNDATION · PI KOTTYAN, LEAH CLAIRE, WEIRAUCH, MATTHEW TYSON · 1987 to 2025
$7.8M
Statistical Methods for the Analysis of ChlP-chip DataR01HG003747 · NHGRI · UNIVERSITY OF WISCONSIN-MADISON · PI KELES, SUNDUZ · 2007 to 2024
$4.8M
NHGRI NIH HHS R01 HG003747NIAID NIH HHS R01 AI024717
6 · The paper itself

Abstract

The Regulators of Complement Activation (RCA) gene cluster comprises several tandemly arranged genes with shared functions within the immune system. RCA members, such as complement receptor 2 (

Indexed as

ChromatinEnhancer Elements, GeneticComplement ActivationGene Expression RegulationMultigene FamilyChromatinB cellschromatin loopingenhancersRCATADs

Identifiers

PMID35769482
PMCPMC9235356
OpenAlexW4282836850

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.