Evidence map›Paper›PMID 35769418›Full record

ArticleERJ open research2022

A genome-wide association study of bronchodilator response in participants of European and African ancestry from six independent cohorts.

Jessica D Gereige, Hanfei Xu, Victor E Ortega, Michael H Cho, Ming Liu, Phuwanat Sakornsakolpat, Edwin K Silverman, Terri H Beaty, Bruce E Miller, Per Bakke and 14 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ERJ open research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 9 institutions in 3 countries.

Jessica D GereigeDivision of Pulmonary, Allergy, Sleep, and Critical Care Medicine, Boston Medical Center, Boston, MA, USA.ORCID https://orcid.org/0000-0003-0755-1131
Hanfei XuDept of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Victor E OrtegaDivision of Genetics, Genomics and Precision Medicine, Department of Medicine, University of Arizona, Tucson, AZ, USA.
Michael H ChoChanning Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID https://orcid.org/0000-0002-4907-1657
Ming LiuChanning Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Phuwanat SakornsakolpatChanning Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID https://orcid.org/0000-0002-4308-0974
Edwin K SilvermanChanning Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Terri H BeatyDept of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA.
Bruce E MillerGSK R&D, Collegeville, PA, USA.ORCID https://orcid.org/0000-0003-3904-3182
Per BakkeDept of Clinical Science, University of Bergen, Bergen, Norway.
Amund GulsvikDept of Clinical Science, University of Bergen, Bergen, Norway.
Craig P HershChanning Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Jarrett D MorrowChanning Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
International COPD Genetics Consortium
Elizabeth J AmplefordDivision of Genetics, Genomics and Precision Medicine, Department of Medicine, University of Arizona, Tucson, AZ, USA.
Gregory A HawkinsDivision of Genetics, Genomics and Precision Medicine, Department of Medicine, University of Arizona, Tucson, AZ, USA.
Eugene R BleeckerDivision of Genetics, Genomics and Precision Medicine, Department of Medicine, University of Arizona, Tucson, AZ, USA.
Deborah A MeyersDivision of Genetics, Genomics and Precision Medicine, Department of Medicine, University of Arizona, Tucson, AZ, USA.
Stephen P PetersDivision of Genetics, Genomics and Precision Medicine, Department of Medicine, University of Arizona, Tucson, AZ, USA.
Juan C CeledónDivision of Pediatric Pulmonary Medicine, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA, USA.ORCID https://orcid.org/0000-0002-6139-5320
Kelan TantisiraDivision of Pediatric Respiratory Medicine, University of California and Rady Children's Hospital, San Diego, CA, USA.
Jiang LiChanning Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Josée DupuisDept of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
George T O'ConnorDivision of Pulmonary, Allergy, Sleep, and Critical Care Medicine, Boston Medical Center, Boston, MA, USA.
Brigham and Women's Hospital · USUniversity of Arizona · USBoston University · USUniversity of Bergen · NOGlaxoSmithKline (United States) · USJohns Hopkins University · USRady Children's Hospital-San Diego · USUniversity of Pittsburgh · USWorcester Polytechnic Institute · US

Funding

Genetic Epidemiology of COPDU01HL089897 · NHLBI · NATIONAL JEWISH HEALTH · PI CRAPO, JAMES D · 2007 to 2021
$56.9M
THE PHARMACOGENETICS OF ASTHMA TREATMENTU01HL065899 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI TANTISIRA, KELAN G, WEISS, SCOTT T · 2000 to 2014
$38.5M
FRAMINGHAM HEART STUDY - YEAR 5 EXAM75N92019D00031 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI RAMACHANDRAN, VASAN · 2019 to 2024
$29.8M
SPIROMICS II: Biological underpinnings of COPD heterogeneity and progressionU01HL137880 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WOODRUFF, PRESCOTT G · 2017 to 2021
$27.9M
BIOLOGY OF THE LUNG--MULTIDISCIPLINARY PROGRAMT32HL007035 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Darrell N. Kotton, JOSEPH P MIZGERD · 1985 to 2026
$24.3M
Genetic Epidemiology of COPDU01HL089856 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SILVERMAN, EDWIN K · 2007 to 2021
$20.7M
(2 of 2) Genetic Epidemiology of COPDR01HL089856 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SILVERMAN, EDWIN K · 2012 to 2016
$18.9M
Leveraging Pharmacogenomics in Asthma for Predication, Mechanism and EndotypingR01HL161362 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI EUGENE ROLAND BLEECKER, GEOFFREY L CHUPP · 2022 to 2026
$8.4M
Effects of Rare Variants and Ancestry on Beta Agonist Response in Asthma and COPDR01HL142992 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ORTEGA, VICTOR E. · 2019 to 2023
$3.7M
Genetic and Functional Dissection of a Cluster of COPD GWAS Signals on Chromosome 4qR01HL147148 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI CHO, MICHAEL H., SILVERMAN, EDWIN K · 2019 to 2022
$3.5M
SYSTEMS GENOMICS OF THE ASTHMA-COPD OVERLAP SYNDROMER01HL130512 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI HERSH, CRAIG P · 2016 to 2019
$3.5M
Identifying functional variants in COPD GWAS lociR01HL137927 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI CHO, MICHAEL H., SILVERMAN, EDWIN K · 2017 to 2020
$3.5M
NHLBI NIH HHS 75N92019D00031NHLBI NIH HHS HHSN268200900013CNHLBI NIH HHS HHSN268200900014CNHLBI NIH HHS HHSN268200900015CNHLBI NIH HHS HHSN268200900016CNHLBI NIH HHS HHSN268200900017CNHLBI NIH HHS HHSN268200900018CNHLBI NIH HHS HHSN268200900019CNHLBI NIH HHS HHSN268200900020CNHLBI NIH HHS HHSN268201500001CNHLBI NIH HHS HHSN268201500001INHLBI NIH HHS K25 HL136846NHLBI NIH HHS N01 HC025195NHLBI NIH HHS R01 HL089856NHLBI NIH HHS R01 HL127332NHLBI NIH HHS R01 HL130512NHLBI NIH HHS R01 HL137927NHLBI NIH HHS R01 HL142992NHLBI NIH HHS R01 HL147148NHLBI NIH HHS R01 HL149861NHLBI NIH HHS R01 HL161362NHLBI NIH HHS T32 HL007035NHLBI NIH HHS U01 HL065899NHLBI NIH HHS U01 HL089856NHLBI NIH HHS U01 HL089897NHLBI NIH HHS U01 HL137880
6 · The paper itself

Abstract

Introduction: Bronchodilator response (BDR) is a measurement of acute bronchodilation in response to short-acting β2-agonists, with a heritability between 10 and 40%. Identifying genetic variants associated with BDR may lead to a better understanding of its complex pathophysiology. Methods: We performed a genome-wide association study (GWAS) of BDR in six adult cohorts with participants of European ancestry (EA) and African ancestry (AA) including community cohorts and cohorts ascertained on the basis of obstructive pulmonary disease. Validation analysis was carried out in two paediatric asthma cohorts. Results: A total of 10 623 EA and 3597 AA participants were included in the analyses. No single nucleotide polymorphism (SNP) was associated with BDR at the conventional genome-wide significance threshold (p<5×10 Conclusion: Ancestry-stratified and ancestry-combined GWAS meta-analyses of over 14 000 participants did not identify genetic variants associated with BDR at the genome-wide significance threshold, although a less stringent threshold identified three variants showing suggestive evidence of association. A common definition and protocol for measuring BDR in research may improve future efforts to identify variants associated with BDR.

Identifiers

PMID35769418
PMCPMC9234425
OpenAlexW4283397944

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