ArticleNational science review2022
Itch perception is reflected by neuronal ignition in the primary somatosensory cortex.
Article in National science review, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 14 citations in OpenAlex.
- Supraspinal Circuit Mechanisms Underlying Itch Processing.CNS neuroscience & therapeutics · 2026Review
- Mechanisms of pruritus and advances in traditional Chinese medicine therapy (Review).Molecular medicine reports · 2026Review
- Central neural circuits underlying itch sensation.Nature reviews. Neuroscience · 2025Review
- High-throughput two-photon volumetric brain imaging in freely moving mice.Nature communications · 2025Article
- Link Brain-Wide Projectome to Neuronal Dynamics in the Mouse Brain.Neuroscience bulletin · 2024Article
- The Anterior Insula and its Projection to the Prelimbic Cortex are Involved in the Regulation of 5-HT-Induced Itch.Neuroscience bulletin · 2023Article
- Miniature three-photon microscopy maximized for scattered fluorescence collection.Nature methods · 2023Article
- Distinct Roles of Dopamine Receptor Subtypes in the Nucleus Accumbens during Itch Signal Processing.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Multiplexed Representation of Itch and Pain and Their Interaction in the Primary Somatosensory Cortex.Experimental neurobiology · 2022Article
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Multiple cortical areas including the primary somatosensory cortex (S1) are activated during itch signal processing, yet cortical representation of itch perception remains unknown. Using novel miniature two-photon microscopic imaging in free-moving mice, we investigated the coding of itch perception in S1. We found that pharmacological inactivation of S1 abolished itch-induced scratching behavior, and the itch-induced scratching behavior could be well predicted by the activity of a fraction of layer 2/3 pyramidal neurons, suggesting that a subpopulation of S1 pyramidal neurons encoded itch perception, as indicated by immediate subsequent scratching behaviors. With a newly established optogenetics-based paradigm that allows precisely controlled pruritic stimulation, we found that a small fraction of S1 neurons exhibited an ignition-like pattern at the detection threshold of itch perception. Our study revealed the neural mechanism underlying itch perceptual coding in S1, thus paving the way for the study of cortical representation of itch perception at the single-neuron level in freely moving animals.
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Registered trials
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