ArticleFrontiers in pediatrics2022
Three Physiological Components That Influence Regional Cerebral Tissue Oxygen Saturation.
Article in Frontiers in pediatrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Cerebral fractional tissue oxygen extraction (cFTOE) during immediate fetal-to-neonatal transition: a systematic qualitative review of the literature.European journal of pediatrics · 2024Pooled it
- Resting and Physical Activity Energy Expenditure Across an Altitudinal Gradient: An Adjusted Analysis.Oxygen (Basel, Switzerland) · 2026Article
- Cerebral Oxygen Saturation Responsiveness During Cardiopulmonary Resuscitation After Prolonged Ventricular Fibrillation: A Porcine Study.Journal of clinical medicine · 2026Article
- Neuroprognostication After Extracorporeal Cardiopulmonary Resuscitation: ECMO-Specific Challenges and a Multimodal Time-Sensitive Framework.Journal of cardiovascular development and disease · 2026Review
- Postnatal Changes in Fetal Hemoglobin and Tissue Oxygenation in Preterm and Term Neonates: A Prospective Observational Study.Neonatology · 2026Article
- Integrated cerebro-splanchnic blood flow and regional oxygenation monitoring in transfused anemic preterm infants.Scientific reports · 2026Observational
- Hemodynamics and cerebral oxygenation in the neonatal transition: a prospective pilot study.Clinical and experimental pediatrics · 2026Article
- Bilateral dynamic cerebral autoregulation assessment during endovascular treatment in large-vessel occlusion stroke.Experimental physiology · 2026Article
- Key physiological indicators and technological trends in physiology-directed cardiopulmonary resuscitation: A narrative review.Resuscitation plus · 2026Review
- Two-year neurodevelopmental outcome in preterm neonates with cerebral oxygenation monitoring after birth: a multinational, multicenter retrospective follow-up study of the COSGOD III trial.Frontiers in pediatrics · 2026Article
- Acid-Base Status and Cerebral Oxygenation in Neonates: A Systematic Qualitative Review of the Literature.Children (Basel, Switzerland) · 2025Review
- Non-invasive cerebral pulse rate monitoring during two low-cardiac-output events after birth - A case report.Resuscitation plus · 2025Article
- The association of regional cerebral oximetry and neurologically intact survival in a porcine model of cardiac arrest.Resuscitation plus · 2024Article
- Acid base and metabolic parameters of the umbilical cord blood and cerebral oxygenation immediately after birth.Frontiers in pediatrics · 2024Article
- Preterm infants variability in cerebral near-infrared spectroscopy measurements in the first 72-h after birth.Pediatric research · 2023Article
- Comparison of Near-Infrared Spectroscopy-Based Cerebral Autoregulatory Indices in Extremely Low Birth Weight Infants.Children (Basel, Switzerland) · 2023Article
- Insights into Neonatal Cerebral Autoregulation by Blood Pressure Monitoring and Cerebral Tissue Oxygenation: A Qualitative Systematic Review.Children (Basel, Switzerland) · 2023Review
- Machine Learning Detects Intraventricular Haemorrhage in Extremely Preterm Infants.Children (Basel, Switzerland) · 2023Article
- Newer indications for neuromonitoring in critically ill neonates.Frontiers in pediatrics · 2023Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Near-infrared spectroscopy (NIRS) measurement of regional cerebral tissue oxygen saturation (rcStO2) has become a topic of high interest in neonatology. Multiple studies have demonstrated that rcStO2 measurements are feasible in the delivery room during immediate transition and resuscitation as well as after admission to the neonatal intensive care unit. Reference ranges for different gestational ages, modes of delivery, and devices have already been published. RcStO2 reflects a mixed tissue saturation, composed of arterial (A), venous (V), and capillary signals, derived from small vessels within the measurement compartment. The A:V signal ratio fluctuates based on changes in oxygen delivery and oxygen consumption, which enables a reliable trend monitoring of the balance between these two parameters. While the increasing research evidence supports its use, the interpretation of the absolute values of and trends in rcStO2 is still challenging, which halts its routine use in the delivery room and at the bedside. To visualize the influencing factors and improve the understanding of rcStO2 values, we have created a flowchart, which focuses on the three major physiological components that affect rcStO2: oxygen content, circulation, and oxygen extraction. Each of these has its defining parameters, which are discussed in detail in each section.
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