Evidence map›Paper›PMID 35769198›Full record

ArticleEnvironmental epigenetics2022

The impact of prenatal and early-life arsenic exposure on epigenetic age acceleration among adults in Northern Chile.

Anne K Bozack, Philippe Boileau, Alan E Hubbard, Fenna C M Sillé, Catterina Ferreccio, Craig M Steinmaus, Martyn T Smith, Andres Cardenas

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environmental epigenetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Quantification of Epigenetic Aging in Public Health.Annual review of public health · 2025
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Anne K BozackDivision of Environmental Health Sciences, School of Public Health, University of California, 2121 Berkeley Way, Room 5302, Berkeley, CA 94720, USA.ORCID https://orcid.org/0000-0003-0046-5767
Philippe BoileauGraduate Group in Biostatistics, University of California, 2121 Berkeley Way, Room 5302, Berkeley, CA 94720, USA.ORCID https://orcid.org/0000-0002-4850-2507
Alan E HubbardGraduate Group in Biostatistics, University of California, 2121 Berkeley Way, Room 5302, Berkeley, CA 94720, USA.
Fenna C M SilléDepartment of Environmental Health and Engineering, The Johns Hopkins University Bloomberg School of Public Health, 615 N. Wolfe Street, Room E7527, Baltimore, MD 21205, USA.
Catterina FerreccioAdvanced Center for Chronic Diseases (ACCDiS), School of Medicine, Pontificia Universidad Católica de Chile, Sergio Livingstone 1007, Independencia, Santiago, Chile.
Craig M SteinmausDivision of Environmental Health Sciences, School of Public Health, University of California, 2121 Berkeley Way, Room 5302, Berkeley, CA 94720, USA.
Martyn T SmithDivision of Environmental Health Sciences, School of Public Health, University of California, 2121 Berkeley Way, Room 5302, Berkeley, CA 94720, USA.
Andres CardenasDivision of Environmental Health Sciences, School of Public Health, University of California, 2121 Berkeley Way, Room 5302, Berkeley, CA 94720, USA.ORCID https://orcid.org/0000-0003-2284-3298
Berkeley Public Health Division · USUniversity of California, Berkeley · USJohns Hopkins University · USPontificia Universidad Católica de Chile · CL

Funding

Training CoreP42ES004705 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI MCHALE, CLIONA · 1987 to 2025
$74.6M
PRENATAL AND POSTNATAL EXPOSURE TO ENVIRONMENTAL MIXTURES: NEURODEVELOPMENT AND DNA METHYLATION BIOMARKERSR01ES031259 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI CARDENAS, ANDRES · 2020 to 2024
$1.9M
NIEHS NIH HHS P42 ES004705NIEHS NIH HHS R01 ES031259
6 · The paper itself

Abstract

Exposure to arsenic affects millions of people globally. Changes in the epigenome may be involved in pathways linking arsenic to health or serve as biomarkers of exposure. This study investigated associations between prenatal and early-life arsenic exposure and epigenetic age acceleration (EAA) in adults, a biomarker of morbidity and mortality. DNA methylation was measured in peripheral blood mononuclear cells (PBMCs) and buccal cells from 40 adults (median age = 49 years) in Chile with and without high prenatal and early-life arsenic exposure. EAA was calculated using the Horvath, Hannum, PhenoAge, skin and blood, GrimAge, and DNA methylation telomere length clocks. We evaluated associations between arsenic exposure and EAA using robust linear models. Participants classified as with and without arsenic exposure had a median drinking water arsenic concentration at birth of 555 and 2 μg/l, respectively. In PBMCs, adjusting for sex and smoking, exposure was associated with a 6-year PhenoAge acceleration [

Indexed as

arsenicenvironmental exposureepigenetic age accelerationperipheral blood mononuclear cells

Identifiers

PMID35769198
PMCPMC9235373
OpenAlexW4281680256

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.