Branch retina vein occlusion combined with angle-closure glaucoma is associated with a mutation in BEST1: a case report.

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In one paragraph

Article in BMC ophthalmology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact, top 88% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Xue YinDepartment of Ophthalmology, Affiliated First Hospital of Soozhow University, Shizi Street 188, Suzhou, 21006, Jiangsu Province, China.

Qinhua CaiDepartment of Ophthalmology, Affiliated First Hospital of Soozhow University, Shizi Street 188, Suzhou, 21006, Jiangsu Province, China. caiqinhua@suda.edu.cn.ORCID http://orcid.org/0000-0001-5825-7958

Soochow University · CN

Funding

National Natural Science Foundation of China 82101120Natural Science Foundation of Jiangsu Province BK20210095Suzhou Municipal Science and Technology Bureau SYS2020114

6 · The paper itself

Abstract

backgroundIt is rare for a patient to be diagnosed with branch retina vein occlusion (BRVO), angle-closure glaucoma (ACG) and autosomal recessive bestrophinopathy (ARB). ARB is strongly associated with ACG. Although glaucoma is a significant risk factor for RVO, there is a plausible relationship between ACG and BRVO. To discuss correlation of these diseases is necessary. CASE PRESENTATION: The genetic testing and medical treatment of a patient with ocular fundus diseases and ACG were recorded. We present a 47-year-old male patient with BRVO who was diagnosed with angle-closure glaucoma and a homozygous mutation of c.140G > A (p.R47H) in BEST1. Intravitreal ranibizumab was administered in combination with three antiglaucomatous eyedrops to lower intraocular pressure (IOP) in the right eye. One month later, BCVA improved to 0.3. IOP was controlled at 13 mmHg.

conclusionsACG was likely combined to ARB, while there's a plausible relationship between ACG and BRVO.

Indexed as

Glaucoma, Angle-ClosureRetinal Vein OcclusionAngiotensin-Converting Enzyme InhibitorsAngiotensin Receptor AntagonistsBestrophinsFluorescein AngiographyHumansIntraocular PressureMaleMiddle AgedMutationRetinaAngiotensin-Converting Enzyme InhibitorsAngiotensin Receptor AntagonistsBEST1 protein, humanBestrophinsAngle-closure glaucomaAutosomal recessive bestrophinopathyBEST1Branch retina vein occlusionCase report

Identifiers

PMID35768830

DOI10.1186/s12886-022-02504-w

PMCPMC9245261

OpenAlexW4283742661

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LicenceCC BY

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.