ArticleThe journal of physiological sciences : JPS2022
Effects of endurance training on metabolic enzyme activity and transporter protein levels in the skeletal muscles of orchiectomized mice.
Article in The journal of physiological sciences : JPS, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 14 citations in OpenAlex.
- Effects of different oxygen concentrations during intermittent hyperoxic training on endurance capacity in well-trained male mice.Physiological reports · 2026Article
- Sex- and age-specific blood lactate recovery kinetics after high-intensity exercise in trained youth: a model-based analysis.European journal of applied physiology · 2026Article
- Hyperactive muscle mTORC1 attenuates functional adaptations to endurance training despite alterations in mitochondrial and lipid profiles.Journal of applied physiology (Bethesda, Md. : 1985) · 2026Article
- Mild hyperbaric oxygen does not attenuate mitochondrial decrease induced by detraining in mice.Biochemistry and biophysics reports · 2025Article
- Article
- Effects of endurance training under calorie restriction on energy substrate metabolism in mouse skeletal muscle and liver.The journal of physiological sciences : JPS · 2024Article
- Effects on Bone and Muscle upon Treadmill Interval Training in Hypogonadal Male Rats.Biomedicines · 2023Article
- Mouse skeletal muscle adaptations to different durations of treadmill exercise after the cessation of FOLFOX chemotherapy.Frontiers in physiology · 2023Article
- Regulation of protein and oxidative energy metabolism are down-regulated in the skeletal muscles of Asiatic black bears during hibernation.Scientific reports · 2022Article
- Inhibition of monocarboxylate transporters (MCT) 1 and 4 reduces exercise capacity in mice.Physiological reports · 2022Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
This study investigated whether endurance training attenuates orchiectomy (ORX)-induced metabolic alterations. At 7 days of recovery after sham operation or ORX surgery, the mice were randomized to remain sedentary or undergo 5 weeks of treadmill running training (15-20 m/min, 60 min, 5 days/week). ORX decreased glycogen concentration in the gastrocnemius muscle, enhanced phosphofructokinase activity in the plantaris muscle, and decreased lactate dehydrogenase activity in the plantaris and soleus muscles. Mitochondrial enzyme activities and protein content in the plantaris and soleus muscles were also decreased after ORX, but preserved, in part, by endurance training. In the treadmill running test (15 m/min, 60 min) after 4 weeks of training, orchiectomized sedentary mice showed impaired exercise performance, which was restored by endurance training. Thus, endurance training could be a potential therapeutic strategy to prevent the hypoandrogenism-induced decline in muscle mitochondrial content and physical performance.
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