Evidence map›Paper›PMID 35768749›Full record

ArticleIndian journal of gastroenterology : official journal of the Indian Society of Gastroenterology2022

Low risk of nosocomial severe acute respiratory syndrome-coronavirus-2 infection in patients with liver disease admitted to a hepatology unit at an academic hospital: A single-center experience.

Pierluigi Toniutto, Federica D'Aurizio, Sara Cmet, Annarosa Cussigh, Edmondo Falleti, Carlo Fabris, Emma Sartor, Ezio Fornasiere, Elisa Fumolo, Davide Bitetto and 1 more

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Article in Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Pierluigi ToniuttoHepatology and Liver Transplantation Unit, Azienda Sanitaria Universitaria Integrata, University Hospital, Udine, Italy. pierluigi.toniutto@uniud.it.ORCID 0000-0002-2566-3041
Federica D'AurizioClinical Pathology, Azienda Sanitaria Universitaria Integrata, University Hospital, Udine, Italy.
Sara CmetClinical Pathology, Azienda Sanitaria Universitaria Integrata, University Hospital, Udine, Italy.
Annarosa CussighClinical Pathology, Azienda Sanitaria Universitaria Integrata, University Hospital, Udine, Italy.
Edmondo FalletiClinical Pathology, Azienda Sanitaria Universitaria Integrata, University Hospital, Udine, Italy.
Carlo FabrisHepatology and Liver Transplantation Unit, Azienda Sanitaria Universitaria Integrata, University Hospital, Udine, Italy.
Emma SartorMicrobiology, Azienda Sanitaria Universitaria Integrata, University Hospital, Udine, Italy.
Ezio FornasiereHepatology and Liver Transplantation Unit, Azienda Sanitaria Universitaria Integrata, University Hospital, Udine, Italy.
Elisa FumoloHepatology and Liver Transplantation Unit, Azienda Sanitaria Universitaria Integrata, University Hospital, Udine, Italy.
Davide BitettoHepatology and Liver Transplantation Unit, Azienda Sanitaria Universitaria Integrata, University Hospital, Udine, Italy.
Francesco CurcioClinical Pathology, Azienda Sanitaria Universitaria Integrata, University Hospital, Udine, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPatients with liver disease may be at increased risk of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection due to immune dysfunction. However, the risk of nosocomial SARS-CoV-2 infection in these patients remains unknown. This study aimed to determine whether patients with liver disease are at an increased risk of nosocomial transmission of SARS-CoV-2 infection upon admission to the hospital for diagnostic or therapeutic procedures.

methodsThe study prospectively enrolled 143 patients who were admitted at least once to the hepatology unit at our hospital; 95 patients (66%) were admitted at least twice during the study period. History of past symptomatic SARS-CoV-2 exposure was assessed on the day before hospital admission via an interview. Patients were evaluated for active SARS-CoV-2 infection via real-time reverse transcription-polymerase chain reaction (RT-PCR) performed on nasopharyngeal swabs and tests for serum anti-SARS-CoV-2 immunoglobulin M (IgM) and immunoglobulin G (IgG) antibodies.

resultsNone of the patients enrolled tested positive for SARS-CoV-2 infection by RT-PCR at the first or the second clinical evaluation. One patient who had previously received a liver transplant and who had a history of symptomatic SARS-CoV-2 infection that occurred 4 months before hospital admission tested positive for anti-SARS-CoV-2 IgG but not IgM antibodies at each of the two hospital admissions.

conclusionsThe results of our study suggest that patients with liver disease are at no increased risk of nosocomial SARS-CoV-2 infection. These data support the policy of maintaining clinical hospital checks that will be necessary until or possibly even after the completion of the current SARS-CoV-2 vaccination campaign.

Indexed as

COVID-19Cross InfectionDigestive System DiseasesGastroenterologyLiver DiseasesAntibodies, ViralCOVID-19 VaccinesHospitalsHumansImmunoglobulin GImmunoglobulin MSARS-CoV-2Antibodies, ViralCOVID-19 VaccinesImmunoglobulin GImmunoglobulin MHepatocellular carcinomaImmunoglobulin GImmunoglobulin MImmunosuppressionLiver cirrhosisLiver transplantationNasopharyngeal swabNosocomial infectionReverse transcriptase polymerase chain reactionSARS-CoV-2 infectionVaccination

Identifiers

PMID35768749
PMCPMC9244468

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.