Evidence map›Paper›PMID 35768747›Full record

ArticleBiometals : an international journal on the role of metal ions in biology, biochemistry, and medicine2023

Effect of bovine lactoferrin on recurrent urinary tract infections: in vitro and in vivo evidences.

Antonietta Lucia Conte, Catia Longhi, Maria Pia Conte, Anna Maria Costanzo, Rosalba Paesano, Stefano Santangeli, Francesco Venditto, Giovanni Tripepi, Enrico Naldi, Giuditta Pollio and 5 more

Abstract read
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In one paragraph

Article in Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Trial
  2. Review
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 1 country.

Antonietta Lucia ConteDepartment of Public Health and Infectious Diseases, University of Rome La Sapienza, Rome, Italy.
Catia LonghiDepartment of Public Health and Infectious Diseases, University of Rome La Sapienza, Rome, Italy.
Maria Pia ConteDepartment of Public Health and Infectious Diseases, University of Rome La Sapienza, Rome, Italy.
Anna Maria CostanzoPharmaguida s.r.l., Salerno, Italy.
Rosalba PaesanoMicrobo s.r.l., Rome, Italy.
Stefano SantangeliGeneral Practitioner, Barberino del Mugello, Florence, Italy.
Francesco VendittoGeneral Practitioner, Florence, Italy.
Giovanni TripepiClinical Epidemiology of Renal Diseases and Hypertension, Institute of Clinical Physiology (IFC), National Research Council (CNR), Ospedali Riuniti, Reggio Calabria, Italy.
Enrico NaldiGeneral Practitioner, Florence, Italy.
Giuditta PollioHematologist, Salerno, Italy.
Valeria CavalliniGynecologist, Latina, Italy.
Marco MarraniGeneral Practitioner, Florence, Italy.
Patrizia FaltoniGynecologist, Florence, Italy.
Piera ValentiDepartment of Public Health and Infectious Diseases, University of Rome La Sapienza, Rome, Italy.
Luigi RosaDepartment of Public Health and Infectious Diseases, University of Rome La Sapienza, Rome, Italy. luigi.rosa@uniroma1.it.ORCID http://orcid.org/0000-0002-1252-6080
Sapienza University of Rome · ITIstituto di Fisiologia Clinica · ITOspedale Santa Maria Goretti · ITUniversity of Salerno · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Uropathogenic Escherichia coli (UPEC) strains are the primary cause of urinary tract infections (UTIs). UPEC strains are able to invade, multiply and persisting in host cells. Therefore, UPEC strains are associated to recurrent UTIs requiring long-term antibiotic therapy. However, this therapy is suboptimal due to the increase of multidrug-resistant UPEC. The use of non-antibiotic treatments for managing UTIs is required. Among these, bovine lactoferrin (bLf), a multifunctional cationic glycoprotein, could be a promising tool because inhibits the entry into the host cells of several intracellular bacteria. Here, we demonstrate that 100 μg/ml bLf hinders the invasion of 2.0 ± 0.5 × 10

Indexed as

CystitisEscherichia coli InfectionsLactoferrinUrinary Tract InfectionsUropathogenic Escherichia coliHumansLactoferrinBovine lactoferrinEscherichia coli CFT073Recurrent cystitisUPEC strainsUTIs

Identifiers

PMID35768747
OpenAlexW4283713079

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.