ArticleCommunications biology2022
Edwardsiella tarda TraT is an anti-complement factor and a cellular infection promoter.
Article in Communications biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 34 citations in OpenAlex.
- Pharmacokinetic-pharmacodynamic evaluation of therapeutic efficacy of intramuscular amoxicillin-florfenicol in olive flounder.Journal of veterinary science · 2026Article
- Edwardsiella tarda Bacteremia Arising From Infected Necrotizing Pancreatitis in a Patient With Cirrhosis.Cureus · 2026Article
- Salmonella enterica persister cells exhibit distinct susceptibility profiles following exposure to human serum and macrophages.PloS one · 2026Article
- Aquatic BPI/LBPs: A Promising Antimicrobial Peptide Resource for Disease Control in Aquaculture.Current protein & peptide science · 2026Review
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- Structure of the conjugation surface exclusion protein TraT.Communications biology · 2025Article
- Field Prevalence and Pathological Features ofAnimals : an open access journal from MDPI · 2025Article
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- The multiverse of CD46 and oncologic interactions.The Journal of clinical investigation · 2025Review
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- Cryo-EM structure and evolutionary history of the conjugation surface exclusion protein TraT.Nature communications · 2025Article
- Pufferfish gasdermin Ea is a significant player in the defense against bacterial pathogens.Marine life science & technology · 2024Article
- Haemolysins are essential to the pathogenicity of deep-seaiScience · 2024Article
- Article
- Type III secretion system effector YfiD inhibits the activation of host poly(ADP-ribose) polymerase-1 to promote bacterial infection.Communications biology · 2024Article
- Genomic investigation unveils high-risk ESBL producingCurrent research in microbial sciences · 2024Article
- Japanese Flounder pol-miR-155 Is Involved inGenes · 2023Article
- Tongue sole creatine kinases function as DAMP and activate antimicrobial immunityFrontiers in immunology · 2023Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Edwardsiella tarda is a well-known bacterial pathogen with a broad range of host, including fish, amphibians, and mammals. One eminent virulence feature of E. tarda is its strong ability to resist the killing of host serum complement, but the involving mechanism is unclear. In this report, we identified E. tarda TraT as a key player in both complement resistance and cellular invasion. TraT, a surface-localized protein, bound and recruited complement factor H onto E. tarda, whereby inhibiting complement activation via the alternative pathway. TraT also interacted with host CD46 in a specific complement control protein domain-dependent manner, whereby facilitating the cellular infection and tissue dissemination of E. tarda. Thus, by acting as an anti-complement factor and a cellular infection promoter, TraT makes an important contribution to the complement evasion and systemic infection of E. tarda. These results add insights into the pathogen-host interaction mechanism during E. tarda infection.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.