Evidence map›Paper›PMID 35768564›Full record

ArticleCommunications biology2022

Activated-memory T cells influence naïve T cell fate: a noncytotoxic function of human CD8 T cells.

Kazuki Sasaki, Mouhamad Al Moussawy, Khodor I Abou-Daya, Camila Macedo, Amira Hosni-Ahmed, Silvia Liu, Mariam Juya, Alan F Zahorchak, Diana M Metes, Angus W Thomson and 2 more

Open access · goldAbstract read
In one paragraph

Article in Communications biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.7field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 3 countries.

Kazuki Sasaki *Department of Surgery, University of Pittsburgh, School of Medicine, Pittsburgh, PA, 15213, USA.
Mouhamad Al Moussawy *Department of Surgery, University of Pittsburgh, School of Medicine, Pittsburgh, PA, 15213, USA.
Khodor I Abou-DayaDepartment of Surgery, University of Pittsburgh, School of Medicine, Pittsburgh, PA, 15213, USA.ORCID 0000-0001-8788-2728
Camila MacedoDepartment of Surgery, University of Pittsburgh, School of Medicine, Pittsburgh, PA, 15213, USA.
Amira Hosni-AhmedDepartment of Chemistry, Division of Biochemistry, Faculty of Science, Fayoum University, Fayoum, 63514, Egypt.
Silvia LiuPittsburgh Liver Research Center, School of Medicine, Pittsburgh, PA, 15213, USA.
Mariam JuyaDepartment of Surgery, University of Pittsburgh, School of Medicine, Pittsburgh, PA, 15213, USA.
Alan F ZahorchakDepartment of Surgery, University of Pittsburgh, School of Medicine, Pittsburgh, PA, 15213, USA.
Diana M MetesDepartment of Surgery, University of Pittsburgh, School of Medicine, Pittsburgh, PA, 15213, USA.
Angus W ThomsonDepartment of Surgery, University of Pittsburgh, School of Medicine, Pittsburgh, PA, 15213, USA.
Fadi G LakkisDepartment of Surgery, University of Pittsburgh, School of Medicine, Pittsburgh, PA, 15213, USA.
Hossam A AbdelsamedDepartment of Surgery, University of Pittsburgh, School of Medicine, Pittsburgh, PA, 15213, USA. abdelsamedha@upmc.edu.ORCID 0000-0002-5448-6056
University of Pittsburgh · USFayoum University · EG

Funding

Pittsburgh Liver Research CenterP30DK120531 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Gavin E Arteel · 2019 to 2026
$10.9M
ImageStreamX MarkIIS10OD019942 · OD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BORGHESI, LISA · 2015 to 2015
$543k
NIDDK NIH HHS P30 DK120531NIH HHS S10 OD019942
6 · The paper itself

Abstract

T cells are endowed with the capacity to sense their environment including other T cells around them. They do so to set their numbers and activation thresholds. This form of regulation has been well-studied within a given T cell population - i.e., within the naïve or memory pool; however, less is known about the cross-talk between T cell subsets. Here, we tested whether memory T cells interact with and influence surrounding naïve T cells. We report that human naïve CD8 T cells (T

Indexed as

Immunologic MemoryMemory T CellsCD8-Positive T-LymphocytesHumansT-Lymphocyte Subsets

Identifiers

PMID35768564
PMCPMC9243096
OpenAlexW4283704842

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.