Evidence map›Paper›PMID 35768548›Full record

ArticleNPJ digital medicine2022

International electronic health record-derived post-acute sequelae profiles of COVID-19 patients.

Harrison G Zhang, Arianna Dagliati, Zahra Shakeri Hossein Abad, Xin Xiong, Clara-Lea Bonzel, Zongqi Xia, Bryce W Q Tan, Paul Avillach, Gabriel A Brat, Chuan Hong and 49 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ digital medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 5 pooled it
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 5 syntheses or guidelines pooled it, 28 citations in OpenAlex.

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  3. Risk of Incident New-Onset Arterial Hypertension After COVID-19 Recovery: A Systematic Review and Meta-analysis.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

59 authors at 20 institutions in 5 countries.

Harrison G Zhang *Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.
Arianna Dagliati *Department of Electrical Computer and Biomedical Engineering, University of Pavia, Pavia, Italy.ORCID http://orcid.org/0000-0002-5041-0409
Zahra Shakeri Hossein AbadDepartment of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.
Xin XiongDepartment of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.ORCID http://orcid.org/0000-0002-1162-5220
Clara-Lea BonzelDepartment of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.
Zongqi XiaDepartment of Neurology, University of Pittsburgh, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0003-1500-2589
Bryce W Q TanDepartment of Medicine, National University Hospital, Singapore, Singapore.
Paul AvillachDepartment of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-0235-7543
Gabriel A BratDepartment of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.
Chuan HongDepartment of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-7056-9559
Michele MorrisDepartment of Biomedical Informatics, University of Pittsburgh, Pittsburgh, PA, USA.
Shyam VisweswaranDepartment of Biomedical Informatics, University of Pittsburgh, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0002-2079-8684
Lav P PatelDepartment of Internal Medicine, Division of Medical Informatics, University Of Kansas Medical Center, Kansas City, MO, USA.ORCID http://orcid.org/0000-0002-8626-137X
Alba Gutiérrez-SacristánDepartment of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-1245-198X
David A HanauerDepartment of Learning Health Sciences, University of Michigan Medical School, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0001-6931-3791
John H HolmesDepartment of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Malarkodi Jebathilagam SamayamuthuDepartment of Biomedical Informatics, University of Pittsburgh, Pittsburgh, PA, USA.
Florence T BourgeoisDepartment of Pediatrics, Harvard Medical School, Boston, MA, USA.
Sehi L'YiDepartment of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-7720-2848
Sarah E MaidlowMichigan Institute for Clinical and Health Research (MICHR) Informatics, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0003-4421-6834
Bertrand MoalIAM unit, Bordeaux University Hospital, Bordeaux, France.
Shawn N MurphyDepartment of Neurology, Massachusetts General Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0002-1905-8806
Zachary H StrasserDepartment of Medicine, Massachusetts General Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0002-4846-6059
Antoine NeurazDepartment of biomedical informatics, Hôpital Necker-Enfants Malade, Assistance Publique Hôpitaux de Paris (APHP), University of Paris, Paris, France.ORCID http://orcid.org/0000-0001-7142-6728
Kee Yuan NgiamDepartment of Biomedical informatics, WiSDM, National University Health Systems Singapore, Singapore, Singapore.ORCID http://orcid.org/0000-0001-5676-2520
Ne Hooi Will LohDepartment of Anaesthesia, National University Health Systems Singapore, Singapore, Singapore.ORCID http://orcid.org/0000-0002-4114-1286
Gilbert S OmennDepartment of Computational Medicine & Bioinformatics, Internal Medicine, Human Genetics, and School of Public Health, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-8976-6074
Andrea PrunottoInstitute of Medical Biometry and Statistics, Faculty of Medicine and Medical Center, University of Freiburg, Freiburg, Germany.
Lauren A DalvinDepartment of Ophthalmology, Mayo Clinic, Rochester, NY, USA.ORCID http://orcid.org/0000-0001-9710-4284
Jeffrey G KlannDepartment of Medicine, Massachusetts General Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0003-2043-1601
Petra SchubertMassachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA.ORCID http://orcid.org/0000-0002-6135-0173
Fernando J Sanz VidorretaDepartment of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Vincent BenoitIT Department, Innovation & Data, APHP Greater Paris University Hospital, Paris, France.ORCID http://orcid.org/0000-0002-7868-5869
Guillaume VerdyIAM unit, Bordeaux University Hospital, Bordeaux, France.
Ramakanth KavuluruDivision of Biomedical Informatics (Department of Internal Medicine), University of Kentucky, Lexington, KY, USA.
Hossein EstiriDepartment of Medicine, Massachusetts General Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0002-0204-8978
Yuan LuoDepartment of Preventive Medicine, Northwestern University, Chicago, IL, USA.ORCID http://orcid.org/0000-0003-0195-7456
Alberto MaloviniLaboratory of Informatics and Systems Engineering for Clinical Research, Istituti Clinici Scientifici Maugeri SpA SB IRCCS, Pavia, Italy.
Valentina TibolloLaboratory of Informatics and Systems Engineering for Clinical Research, Istituti Clinici Scientifici Maugeri SpA SB IRCCS, Pavia, Italy.ORCID http://orcid.org/0000-0003-2687-3822
Riccardo BellazziDepartment of Electrical, Computer and Biomedical Engineering, University of Pavia, Pavia, Italy.
Kelly ChoMassachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA.
Yuk-Lam HoMassachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA.ORCID http://orcid.org/0000-0003-3305-3830
Amelia L M TanDepartment of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0003-0623-6623
Byorn W L TanDepartment of Medicine, National University Hospital, Singapore, Singapore.
Nils GehlenborgDepartment of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.
Sara Lozano-ZahoneroInstitute of Medical Biometry and Statistics, Faculty of Medicine and Medical Center, University of Freiburg, Freiburg, Germany.
Vianney JouhetIAM unit, INSERM Bordeaux Population Health ERIAS TEAM, Bordeaux University Hospital / ERIAS - Inserm, U1219 BPH, Bordeaux, France.ORCID http://orcid.org/0000-0001-5272-2265
Luca ChiovatoUnit of Internal Medicine and Endocrinology, Istituti Clinici Scientifici Maugeri SpA SB IRCCS, Pavia, Italy.
Bruce J AronowDepartments of Biomedical Informatics, Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH, USA.ORCID http://orcid.org/0000-0001-5109-6514
Emma M S TohYong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Wei Gen Scott WongDepartment of Medicine, National University Health Systems Singapore, Singapore, Singapore.ORCID http://orcid.org/0000-0001-5191-154X
Sara PizzimentiScientific Direction, IRCCS Ca' Granda Ospedale Maggiore Policlinico di Milano, Milan, Italy.
Kavishwar B WagholikarDepartment of Medicine, Massachusetts General Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0002-6219-861X
Mauro BucaloBIOMERIS (BIOMedical Research Informatics Solutions), Pavia, Italy.ORCID http://orcid.org/0000-0002-0407-6120
Consortium for Clinical Characterization of COVID-19 by EHR (4CE)
Tianxi Cai *Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-5379-2502
Andrew M South *Department of Pediatrics-Section of Nephrology, Brenner Children's, Wake Forest School of Medicine, Winston Salem, NC, USA.ORCID http://orcid.org/0000-0002-3204-4142
Isaac S Kohane *Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0003-2192-5160
Griffin M Weber *Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA. weber@hms.harvard.edu.
Harvard University · USMassachusetts General Hospital · USUniversity of Pittsburgh · USIstituti Clinici Scientifici Maugeri · ITNational University Health System · SGUniversity of Michigan · USVA Boston Healthcare System · USCentre Hospitalier Universitaire de Bordeaux · FRNational University Hospital · SGUniversity of Freiburg · DEUniversity of Pavia · ITBrenner Children's Hospital · USCincinnati Children's Hospital Medical Center · USFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico · ITHôpital Necker-Enfants Malades · FRMayo Clinic · USNational University of Singapore · SGNorthwestern University · USResearch Medical Center · USUniversité de Bordeaux · FR

Funding

University of Pittsburgh Clinical and Translational Science InstituteUL1TR001857 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2016 to 2025
$129.3M
UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
The Harvard Clinical and Translational Science CenterUL1TR002541 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2018 to 2022
$93.0M
Michigan Institute for Clinical and Health Research (MICHR)UL1TR002240 · NCATS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LUMENG, JULIE C, MASHOUR, GEORGE ALEXANDER · 2017 to 2022
$54.9M
University of Pittsburgh Clinical and Translational Science InstituteUL1TR000005 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2012 to 2015
$50.8M
RADx-UP: Improving the Response of Local Urban and Rural Communities to Disparities in Covid-19 TestingUL1TR002366 · NCATS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI Mario Castro, JAMES STEVEN LEEDER · 2017 to 2026
$44.3M
Kentucky Center for Clinical and Translational ScienceUL1TR001998 · NCATS · UNIVERSITY OF KENTUCKY · PI HARTMANN, KATHERINE E, KERN, PHILIP A · 2016 to 2025
$34.2M
RESEARCH TRAINING-MEDICAL INFORMATICS 90T15LM007092 · NLM · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI Nils Gehlenborg · 1992 to 2026
$32.8M
Wake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3M
Strategic Vision & Impact on Environmental HealthP30ES017885 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI STUART A BATTERMAN · 2011 to 2026
$21.3M
Finding Genomic Profiles of COVID-19 Phenotypes from the EHRU01HG008685 · NHGRI · BRIGHAM AND WOMEN'S HOSPITAL · PI ELIZABETH W KARLSON, Matthew S Lebo · 2015 to 2026
$13.6M
The LungMAP Data Coordination Center for Next Gen Systems Biology of RespirationU24HL148865 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI Bruce J Aronow, Nathan G. Salomonis · 2019 to 2026
$12.4M
NCATS NIH HHS UL1 TR000005NCATS NIH HHS UL1 TR001420NCATS NIH HHS UL1 TR001857NCATS NIH HHS UL1 TR001881NCATS NIH HHS UL1 TR001998NCATS NIH HHS UL1 TR002240NCATS NIH HHS UL1 TR002366NCATS NIH HHS UL1 TR002541NCI NIH HHS U24 CA210967NHGRI NIH HHS R01 HG009174NHGRI NIH HHS U01 HG008685NHLBI NIH HHS K23 HL148394NHLBI NIH HHS L40 HL148910NHLBI NIH HHS R01 HL151643NHLBI NIH HHS U24 HL148865NIEHS NIH HHS P30 ES017885NINDS NIH HHS R01 NS098023NINDS NIH HHS R01 NS124882NLM NIH HHS R01 LM013337NLM NIH HHS R01 LM013345NLM NIH HHS T15 LM007092U.S. Department of Health & Human Services | National Institutes of Health (NIH) P30ES017885U.S. Department of Health & Human Services | National Institutes of Health (NIH) U24CA210967U.S. Department of Health & Human Services | NIH | National Center for Advancing Translational Sciences (NCATS) 5UL1TR001857-05U.S. Department of Health & Human Services | NIH | National Center for Advancing Translational Sciences (NCATS) CTSA Award #UL1TR002366U.S. Department of Health & Human Services | NIH | National Center for Advancing Translational Sciences (NCATS) UL1TR000005U.S. Department of Health & Human Services | NIH | National Center for Advancing Translational Sciences (NCATS) UL1TR001420U.S. Department of Health & Human Services | NIH | National Center for Advancing Translational Sciences (NCATS) UL1TR001857U.S. Department of Health & Human Services | NIH | National Center for Advancing Translational Sciences (NCATS) UL1TR001881U.S. Department of Health & Human Services | NIH | National Center for Advancing Translational Sciences (NCATS) UL1TR001998U.S. Department of Health & Human Services | NIH | National Center for Advancing Translational Sciences (NCATS) UL1TR002240U.S. Department of Health & Human Services | NIH | National Center for Advancing Translational Sciences (NCATS) UL1TR002541U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) K23HL148394U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) L40HL148910U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01 HL151643-01U.S. Department of Health & Human Services | NIH | National Human Genome Research Institute (NHGRI) 3U01HG008685-05S2U.S. Department of Health & Human Services | NIH | National Human Genome Research Institute (NHGRI) 5R01HG009174-04U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) R01NS098023U.S. Department of Health & Human Services | NIH | U.S. National Library of Medicine (NLM) R01LM013337U.S. Department of Health & Human Services | NIH | U.S. National Library of Medicine (NLM) R01LM013345
6 · The paper itself

Abstract

The risk profiles of post-acute sequelae of COVID-19 (PASC) have not been well characterized in multi-national settings with appropriate controls. We leveraged electronic health record (EHR) data from 277 international hospitals representing 414,602 patients with COVID-19, 2.3 million control patients without COVID-19 in the inpatient and outpatient settings, and over 221 million diagnosis codes to systematically identify new-onset conditions enriched among patients with COVID-19 during the post-acute period. Compared to inpatient controls, inpatient COVID-19 cases were at significant risk for angina pectoris (RR 1.30, 95% CI 1.09-1.55), heart failure (RR 1.22, 95% CI 1.10-1.35), cognitive dysfunctions (RR 1.18, 95% CI 1.07-1.31), and fatigue (RR 1.18, 95% CI 1.07-1.30). Relative to outpatient controls, outpatient COVID-19 cases were at risk for pulmonary embolism (RR 2.10, 95% CI 1.58-2.76), venous embolism (RR 1.34, 95% CI 1.17-1.54), atrial fibrillation (RR 1.30, 95% CI 1.13-1.50), type 2 diabetes (RR 1.26, 95% CI 1.16-1.36) and vitamin D deficiency (RR 1.19, 95% CI 1.09-1.30). Outpatient COVID-19 cases were also at risk for loss of smell and taste (RR 2.42, 95% CI 1.90-3.06), inflammatory neuropathy (RR 1.66, 95% CI 1.21-2.27), and cognitive dysfunction (RR 1.18, 95% CI 1.04-1.33). The incidence of post-acute cardiovascular and pulmonary conditions decreased across time among inpatient cases while the incidence of cardiovascular, digestive, and metabolic conditions increased among outpatient cases. Our study, based on a federated international network, systematically identified robust conditions associated with PASC compared to control groups, underscoring the multifaceted cardiovascular and neurological phenotype profiles of PASC.

Identifiers

PMID35768548
PMCPMC9242995
OpenAlexW4283707533

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.